Corma-Gómez, AnaïsMacías, JuanRivero, AntonioRivero-Juarez, Antoniode Los Santos, IgnacioReus-Bañuls, SergioMorano, LuisMerino, DoloresPalacios, RosarioGalera, CarlosFernández-Fuertes, MartaGonzález-Serna, Alejandrode Rojas, ItziarRuiz, AgustínSáez, María E.Real, Luis M.Pineda, Juan A.2022-11-092022-11-092021-08-20Corma-Gómez A, Macías J, Rivero A, Rivero-Juarez A, de Los Santos I, Reus-Bañuls S, et al. A Genome-Wide Association Study on Liver Stiffness Changes during Hepatitis C Virus Infection Cure. Diagnostics. 2021 Aug 20;11(8):1501http://hdl.handle.net/10668/4346Liver stiffness (LS) at sustained virological response (SVR) after direct-acting antivirals (DAA)-based therapy is a predictor of liver events in hepatitis C virus (HCV)-infected patients. The study aim was to identify genetic factors associated with LS changes from the moment of starting anti-HCV therapy to SVR. This prospective study included HCV-infected patients from the GEHEP-011 cohort who achieved SVR with DAA-based therapy, with LS pre-treatment ≥ 9.5 kPa and LS measurement available at SVR. Plink and Magma software were used to carry out genome-wide single-nucleotide polymorphism (SNP)-based and gene-based association analyses, respectively. The ShinyGO application was used for exploring enrichment in Gene Ontology (GO) categories for biological processes. Overall, 242 patients were included. Median (quartile 1, quartile 3) LS values at pre-treatment and at SVR were 16.8 (12, 28) kPa and 12.0 (8.5, 19.3) kPa, respectively. Thirty-five SNPs and three genes reached suggestive association with LS changes from the moment of starting anti-HCV therapy to SVR. GO categories related to DNA packaging complex, DNA conformation change, chromosome organization and chromatin organization were significantly enriched. Our study reports possible genetic factors associated with LS changes during HCV-infection cure. In addition, our results suggest that processes related to DNA conformation are also involved in these changes.11 p.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/GWASHepatitis C virus infectionPolymorphismsSustained virological responseDirect-acting antiviralsLiver stiffnessChromatinDNA PackagingEstudio de asociación del genoma completoHepatitis CHepacivirusPolimorfismo de nucleótido simpleAntiviralesCromatinaEmpaquetamiento del ADNMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Antiviral AgentsMedical Subject Headings::Organisms::Viruses::Hepatitis Viruses::HepacivirusMedical Subject Headings::Diseases::Virus Diseases::Hepatitis, Viral, Human::Hepatitis C::Hepatitis C, ChronicMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective StudiesMedical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics::Genetic Research::Gene OntologyMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single NucleotideMedical Subject Headings::Anatomy::Cells::Cellular Structures::Intracellular Space::Cell Nucleus::Cell Nucleus Structures::Intranuclear Space::Chromosomes::Chromosome Structures::ChromatinMedical Subject Headings::Phenomena and Processes::Biological PhenomenaMedical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Molecular Structure::Molecular Conformation::Nucleic Acid ConformationMedical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::DNA PackagingMedical Subject Headings::Chemicals and Drugs::Carbohydrates::Glycosides::NucleotidesMedical Subject Headings::Anatomy::Cells::Cellular Structures::ChromosomesMedical Subject Headings::Information Science::Information Science::Computing Methodologies::Softwareresearch article34441435open access10.3390/diagnostics110815012075-4418PMC8394459