Arcelus, Juan IgnacioMonreal, ManuelCaprini, Joseph AGutiérrez Guisado, JavierSoto, Mª JoséNúñez, Manuel JesúsAlvárez, Juan Carlos2012-11-082012-11-082008-03-03Arcelus JI, Monreal M, Caprini JA, Gutiérrez Guisado J, Soto MJ, Núñez MJ et al. Clinical presentation and time-course of postoperative venous thromboembolism: Results from the RIETE Registry.Thromb Haemost. 2008 Mar;99(3):546-510340-6245http://hdl.handle.net/10668/609Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't;There is little literature about the clinical presentation and time-course of postoperative venous thromboembolism (VTE) in different surgical procedures. RIETE is an ongoing, prospective registry of consecutive patients with objectively confirmed, symptomatic acute VTE. In this analysis, we analysed the baseline characteristics, thromboprophylaxis and therapeutic patterns, time-course, and three-month outcome of all patients with postoperative VTE. As of January 2006, there were 1,602 patients with postoperative VTE in RIETE: 393 (25%) after major orthopaedic surgery (145 elective hip arthroplasty, 126 knee arthroplasty, 122 hip fracture); 207 (13%) after cancer surgery; 1,002 (63%) after other procedures. The percentage of patients presenting with clinically overt pulmonary embolism (PE) (48%, 48%, and 50% respectively), the average time elapsed from surgery to VTE (22 +/- 16, 24 +/- 16, and 21 +/- 15 days, respectively), and the three-month incidence of fatal PE (1.3%, 1.4%, and 0.8%, respectively), fatal bleeding (0.8%, 1.0%, and 0.2%, respectively), or major bleeding (2.3%, 2.9%, and 2.8%, respectively) were similar in the three groups. However, the percentage of patients who had received thromboprophylaxis (96%, 76% and 52%, respectively), the duration of prophylaxis (17 +/- 9.6, 13 +/- 8.9, and 12 +/- 11 days, respectively) and the mean daily doses of low-molecular-weight heparin (4,252 +/- 1,016, 3,260 +/- 1,141, and 3,769 +/- 1,650 IU, respectively), were significantly lower in those undergoing cancer surgery or other procedures. In conclusion, the clinical presentation, time-course, and three-month outcome of VTE was similar among the different subgroups of patients, but the use of prophylaxis in patients undergoing cancer surgery or other procedures was suboptimal.enAncianosArgentinaEuropa ( Continente)FemeninoFibrinolíticosHemorragiaHumanosIncidenciaIsraelMasculinoMediana edadNeoplasiasProcedimientos ortopédicosEstudios prospectivosEmbolia pulmonarRecurrencia local de neoplasiaSistema de registrosProcedimientos quirúrgicosFactores de tiempoTromboembolia venosaSurgeryVenous thromboembolismMedical Subject Headings::Geographicals::Geographic Locations::Americas::South America::ArgentinaMedical Subject Headings::Geographicals::Geographic Locations::EuropeMedical Subject Headings::Check Tags::FemaleMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Fibrin Modulating Agents::Fibrinolytic AgentsMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::HemorrhageMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::IncidenceMedical Subject Headings::Geographicals::Geographic Locations::Asia::Asia, Western::Middle East::IsraelMedical Subject Headings::Check Tags::MaleMedical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle AgedMedical Subject Headings::Diseases::NeoplasmsMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Orthopedic ProceduresMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective StudiesMedical Subject Headings::Diseases::Respiratory Tract Diseases::Lung Diseases::Pulmonary EmbolismMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::RecurrenceMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::RegistriesMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, OperativeMedical Subject Headings::Phenomena and Processes::Physical Phenomena::Time::Time FactorsMedical Subject Headings::Diseases::Cardiovascular Diseases::Vascular Diseases::Embolism and Thrombosis::Thromboembolism::Venous ThromboembolismMedical Subject Headings::Named Groups::Persons::Age Groups::Adult::Agedresearch article18327403open access10.1160/TH07-10-0611