Muñoz-Navarro, RogerMedrano, Leonardo AdrianLimonero, Joaquin TGonzalez-Blanch, CesarMoriana, Juan ARuiz-Rodriguez, PalomaCano-Vindel, Antonio2023-05-032023-05-032022-01-04Muñoz-Navarro R, Medrano LA, Limonero JT, González-Blanch C, Moriana JA, Ruiz-Rodríguez P, et al. The mediating role of emotion regulation in transdiagnostic cognitive behavioural therapy for emotional disorders in primary care: Secondary analyses of the PsicAP randomized controlled trial. J Affect Disord. 2022 Apr 15;303:206-215http://hdl.handle.net/10668/22287Emotional disorders are highly prevalent in primary care. Transdiagnostic cognitive behavior therapy (TD-CBT) is a promising treatment of emotional disorders. In this study, we evaluated several emotion regulation strategies as potential mediators of treatment outcomes in a clinical sample of primary care. A total of 1061 primary care patients were included in a randomized clinical trial comparing treatment-as-usual (TAU) to TD-CBT+TAU. Of these, 631 (TAU=316; TD-CBT+TAU=315) completed the full treatment and all pre- and post-treatment scales to assess symptoms (anxiety, depression, somatization), emotion regulation strategies (worry, rumination, negative metacognition, suppression, cognitive reappraisal), overall functioning, and quality of life (QoL). Treatment and direct effects showed that TD-CBT+TAU was superior to TAU alone. On the multivariate mediation analysis of indirect effects, three maladaptive strategies (worry, rumination and negative metacognition) had significant effects on all emotional symptoms. Suppression was also significant for depression. Rumination and negative metacognition were significant mediators of functioning, while only negative metacognition was significant for QoL. Reappraisal had no effect on any outcome. We focused mainly on maladaptive cognitive emotion regulation strategies and only studied one behavioural strategy (suppression) and one adaptive strategy (reappraisal). Targeting certain maladaptive emotion regulation strategies (worry, rumination, suppression, negative metacognition) as mediators for treatment with TD-CBT could reduce emotional symptoms and improve well-being. Negative metacognition was the most transdiagnostic strategy, whereas an adaptive strategy such as reappraisal was not a mediator. Thus, maladaptive emotion regulation strategies are key mediators in transdiagnostic therapy for emotional disorders in primary care.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/AnxietyCognitive behavioural therapyDepressionEmotion regulationMediatorsRandomized clinical trialSomatizationTransdiagnosticAnxiety disordersCognitive behavioral therapyEmotional regulationEmotionsHumansPrimary health careQuality of liferesearch article34998804open accessAtención primaria de saludCalidad de vidaEmocionesRegulación emocionalTerapia cognitivo-conductualTrastornos de ansiedad10.1016/j.jad.2022.01.0291573-2517https://doi.org/10.1016/j.jad.2022.01.029