Ortiz-Marquez, F.Padilla-Leiva, C.Cabezudo-Garcia, P.Diaz-Cordobes, G.Munoz-Becerra, L.Mena-Vazquez, N.2023-05-032023-05-032022-05-23Ortiz-Márquez, F., Padilla-Leiva, C., Cabezudo-García, P., Diaz-Cordobes, G., Muñoz-Becerra, L., & Mena-Vázquez, N. (2022). AB1240 PROSPECTIVE EVALUATION OF COGNITIVE FUNCTION IN PATIENTS WITH JUVENILE IDIOPATHIC ARTHRITIS. Annals Of The Rheumatic Diseases, 81(Suppl 1), 1731.3-17320003-4967http://hdl.handle.net/10668/20084Background: Juvenile idiopathic arthritis (JIA) is a chronic disease requiring years of therapy with non-steroidal anti-inflammatory drugs (NSAIDs), immunosuppressant’s, cytostatics, immunobiological agents. The aforementioned drugs, namely NSAIDs and cytostatics are potentially nephrotoxic [1]. The above drugs, namely NSAIDs and cytostatics, are potentially nephrotoxic. About 8% of children with JIA have kidney damage, which develops on average 5 years after the onset of the disease. It has been established that the main risk factor for the development of kidney damage is the long-term exposure to NSAIDs and methotrexate in children with active forms of JIA [2]. Early diagnosis of kidney damage will allow timely correction in the dosage of drugs and avoid their nephrotoxic effects [3]. Objectives: To determine the effect of drug therapy in children with JIA on eGFR by using the Cystatin C-based equation and the Hoek formula based on the serum cystatin C study. Methods: 80 children with JIA participated in the study. The age of subjects was 10.4±4.41 (10.6-15.0) years. All children received methotrexate as a base drug. At the moment of examination 22 children received NSAIDs, 25 children received immunobiological preparations. Serum cystatin C content was determined by enzyme immunoassay. The Cystatin C-based equation 2012 and Hoek formulas were used to set the GFR by serum cystatin C levels.enMethotrexateArthritis, JuvenileImmunosuppressive AgentsCytostatic AgentsAnti-Inflammatory Agents, Non-SteroidalCystatin CAntibodiesKidney DiseasesChronic DiseaseImmunoenzymconference outputRestricted AccessCistatina CAntiinflamatorios no EsteroideosEnfermedad crónicaArtritis juvenilInmunosupresores10.1136/annrheumdis-2022-eular.21591468-2060https://ard.bmj.com/content/annrheumdis/81/Suppl_1/1731.3.full.pdf850279007179