Mensa, JosepBarberan, JoseFerrer, RicardBorges, MarcioRascado, PedroMaseda, EmilioOliver, AntonioMarco, FrancescAdalia, RamonAguilar, GerardoEstella, AngelLeon Lopez, RafaelRobles Marcos, Manuel S.Gonzalez de Molina, Fco J.Serrano Garcia, RicardoSalavert, MiguelFernandez Gomez, JavierPoliakova, YuliyaPasquau, JuanRamon Azanza, JoseBou Arevalo, GermanLLinares Mondejar, PedroCardinal-Fernandez, PabloSoriano, Alex2025-01-072025-01-072021-10-010214-3429https://hdl.handle.net/10668/25097Severe infection and its evolution to sepsis are becoming more prevalent every day and are among the leading causes of critical illness and mortality. Proper management is crucial to improve prognosis. This document addresses three essential points that have a significant impact on this objective: a) early recognition of patients with sepsis criteria, b) identification of those patients who suffer from an infection and have a high risk of progressing to sepsis, and c) adequate selection and optimization of the initial antimicrobial treatment.enAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/sepsisseptic shocksevere infectionselection and optimization of antimicrobial treatmentceftazidime-avibactamceftolozane-tazobactammeropenemC-reactive proteinBlood-stream infectionsInternational consensus definitionsKlebsiella-pneumoniae infectionCommunity-acquired pneumoniaIntensive-care unitsAcute kidney injurySeptic shockSevere sepsisAntimicrobial therapyresearch article34693705open access10.37201/req/126.20211988-9518https://seq.es/wp-content/uploads/2021/10/mensa25oct2021.pdf747670800018