Serrano Garballo, AlfonsoCastro Vega, IsabelRedondo, Maximino2013-01-142013-01-142011-07-18Serrano Garballo A, Castro-Vega I, Redondo M. Role of gene methylation in antitumor immune response: Implication for tumor progression. Cancers. 2011;3(2):1672-1690http://hdl.handle.net/10668/742Cancer immunosurveillance theory has emphasized the role of escape mechanisms in tumor growth. In this respect, a very important factor is the molecular characterization of the mechanisms by which tumor cells evade immune recognition and destruction. Among the many escape mechanisms identified, alterations in classical and non-classical HLA (Human Leucocyte Antigens) class I and class II expression by tumor cells are of particular interest. In addition to the importance of HLA molecules, tumor-associated antigens and accessory/co-stimulatory molecules are also involved in immune recognition. The loss of HLA class I antigen expression and of co-stimulatory molecules can occur at genetic, transcriptional and post-transcriptional levels. Epigenetic defects are involved in at least some mechanisms that preclude mounting a successful host-antitumor response involving the HLA system, tumor-associated antigens, and accessory/co-stimulatory molecules. This review summarizes our current understanding of the role of methylation in the regulation of molecules involved in the tumor immune response.enEnfermedades GastrointestinalesNeoplasias HematológicasLínea Celular TumoralAzacitidina5,6-DihidroxitriptaminaProteínas PortadorasInhibidor p16 de la Quinasa Dependiente de CiclinaADNMetilasas de Modificación del ADNInhibidores de Histona DesacetilasasAntígenos HLAInterleucina-10Antígeno MART-1Proteínas Quinasas Mitógeno ActivadasSubfamilia K de Receptores Similares a Lectina de Células NKProteínas rasTransportadoras de Casetes de Unión a ATPÁcidos HidroxámicosCitidinaMetilación de ADNEscape del TumorClusterinaMedical Subject Headings::Diseases::Digestive System Diseases::Gastrointestinal DiseasesMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Hematologic NeoplasmsMedical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, TumorMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Aza Compounds::AzacitidineMedical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Indoles::Tryptamines::Dihydroxytryptamines::5,6-DihydroxytryptamineMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Carrier ProteinsMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intracellular Signaling Peptides and Proteins::Cyclin-Dependent Kinase Inhibitor Proteins::Cyclin-Dependent Kinase Inhibitor p16Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNAMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::One-Carbon Group Transferases::Methyltransferases::DNA Modification MethylasesMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::Histone Deacetylase InhibitorsMedical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Antigens, Surface::Histocompatibility Antigens::HLA AntigensMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Interleukins::Interleukin-10Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Neoplasm Proteins::Melanoma-Specific Antigens::MART-1 AntigenMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Serine-Threonine Kinases::Mitogen-Activated Protein KinasesMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Immunologic::Receptors, Natural Killer Cell::Receptors, NK Cell Lectin-Like::NK Cell Lectin-Like Receptor Subfamily KMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Acid Anhydride Hydrolases::GTP Phosphohydrolases::GTP-Binding Proteins::Monomeric GTP-Binding Proteins::ras ProteinsMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Membrane Transport Proteins::ATP-Binding Cassette TransportersMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amines::Hydroxylamines::Hydroxamic AcidsMedical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Pyrimidines::Pyrimidine Nucleosides::CytidineMedical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::DNA MethylationMedical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immune System Processes::Tumor EscapeMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Clusterinresearch articleopen access10.3390/cancers30216722072-6694