García-Delgado, ManuelNavarrete-Sánchez, InésChamorro-Marín, VirginiaDíaz-Monrové, Juan CarlosEsquivias, JavierFernández-Mondéjar, Enrique2013-04-152013-04-152012García-Delgado M, Navarrete-Sánchez I, Chamorro-Marín V, Díaz-Monrové JC, Esquivias J, Fernández-Mondéjar E. Alveolar overdistension as a cause of lung injury: differences among three animal species. ScientificWorldJournal; 2012:985923http://hdl.handle.net/10668/902Journal Article;This study analyses characteristics of lung injuries produced by alveolar overdistension in three animal species. Mechanical ventilation at normal tidal volume (10 mL/Kg) and high tidal volume (50 mL/Kg) was applied for 30 min in each species. Data were gathered on wet/dry weight ratio, histological score, and area of alveolar collapse. Five out of six rabbits with high tidal volume developed tension pneumothorax, and the rabbit results were therefore not included in the histological analysis. Lungs from the pigs and rats showed minimal histological lesions. Pigs ventilated with high tidal volume had significantly greater oedema, higher neutrophil infiltration, and higher percentage area of alveolar collapse than rats ventilated with high tidal volume. We conclude that rabbits are not an appropriate species for in vivo studies of alveolar overdistension due to their fragility. Although some histological lesions are observed in pigs and rats, the lesions do not appear to be relevant.enPulmónLesión PulmonarNeumotóraxRespiración con Presión PositivaAlveolos PulmonaresConejosRatasRatas WistarRespiración ArtificialMecánica RespiratoriaEspecificidad de la EspeciePorcinosVolumen de Ventilación PulmonarAnimalesMedical Subject Headings::Anatomy::Respiratory System::LungMedical Subject Headings::Diseases::Respiratory Tract Diseases::Lung Diseases::Lung InjuryMedical Subject Headings::Diseases::Respiratory Tract Diseases::Pleural Diseases::PneumothoraxMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Airway Management::Respiration, Artificial::Positive-Pressure RespirationMedical Subject Headings::Anatomy::Respiratory System::Lung::Pulmonary AlveoliMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Lagomorpha::RabbitsMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::RatsMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats::Rats, WistarMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Airway Management::Respiration, ArtificialMedical Subject Headings::Phenomena and Processes::Circulatory and Respiratory Physiological Phenomena::Respiratory Physiological Phenomena::Respiratory Physiological Processes::Respiration::Respiratory MechanicsMedical Subject Headings::Phenomena and Processes::Biological Phenomena::Species SpecificityMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Artiodactyla::SwineMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Techniques, Respiratory System::Respiratory Function Tests::Lung Volume Measurements::Total Lung Capacity::Vital Capacity::Inspiratory Capacity::Tidal VolumeMedical Subject Headings::Organisms::Eukaryota::Animalsresearch article22645503open access10.1100/2012/9859231537-744XPMC3356768