Mancebo-Perez, CristinaVidal, MartaAguilar, RuthBarrios, DianaBardaji, AzucenaOme-Kaius, MariaMenendez, ClaraRogerson, Stephen JDobaño, CarlotaMoncunill, GemmaRequena, Pilar2023-05-032023-05-032022-11-07Mancebo-Pérez C, Vidal M, Aguilar R, Barrios D, Bardají A, Ome-Kaius M, et al. Eotaxin-2 and eotaxin-3 in malaria exposure and pregnancy. Malar J. 2022 Nov 15;21(1):336.http://hdl.handle.net/10668/20321Eotaxin-1 concentrations in plasma have been inversely associated with malaria exposure, malaria infection and pregnancy, but the effect of these conditions on the levels of the related chemokines eotaxin-2 and eotaxin-3 remains unknown. Eotaxin-2 and -3 concentrations were measured in 310 peripheral or placental plasma samples from pregnant and non-pregnant individuals from Papua New Guinea (malaria-endemic country) and Spain (malaria-naïve individuals) with previous data on eotaxin-1 concentrations. Correlations between eotaxin concentrations were examined with the Spearman's test. Differences in eotaxin concentrations among groups were evaluated with the Kruskal-Wallis or Mann Whitney tests. The pairwise Wilcoxon test was performed to compare eotaxin-2 concentration between peripheral and placental matched plasmas. Univariable and multivariable linear regression models were estimated to assess the association between eotaxins and Plasmodium infection or gestational age. Eotaxin-2 concentrations in plasma showed a weak positive correlation with eotaxin-3 (rho = 0.35, p  Although a clear epidemiological negative association is observed between eotaxins concentrations and malaria exposure and/or infection, pregnancy may alter this association for eotaxin-2. Further research is required to understand the role of these chemokines in this disease and in combination with pregnancy.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/ChemokineEotaxinMalariaPlacentaPregnancyFemaleHumansPregnancyChemokine CCL11Chemokine CCL24Chemokine CCL26Immunoglobulin GMalariaMalaria, FalciparumPlacentaPlasmodium falciparumPregnancy Complications, InfectiousPregnancy Complications, Parasiticresearch article36380370open accessComplicaciones infecciosas del embarazoComplicaciones parasitarias del embarazoEmbarazoFemeninoHumanosInmunoglobulina GMalariaMalaria falciparumPlacentaPlasmodium falciparumQuimiocina CCL11Quimiocina CCL24Quimiocina CCL2610.1186/s12936-022-04372-71475-2875PMC9667598https://malariajournal.biomedcentral.com/counter/pdf/10.1186/s12936-022-04372-7https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667598/pdf