Tulipani, SaraPalau-Rodriguez, MagaliMiñarro Alonso, AntonioCardona, FernandoMarco-Ramell, AnnaZonja, BozoLopez de Alda, MirenMuñoz-Garach, AraceliSanchez-Pla, AlejandroTinahones, Francisco JAndres-Lacueva, Cristina2023-01-252023-01-252016-10-05http://hdl.handle.net/10668/10521Metabolomic studies aimed to dissect the connection between the development of type 2 diabetes and obesity are still scarce. In the present study, fasting serum from sixty-four adult individuals classified into four sex-matched groups by their BMI [non-obese versus morbid obese] and the increased risk of developing diabetes [prediabetic insulin resistant state versus non-prediabetic non-insulin resistant] was analyzed by LC- and FIA-ESI-MS/MS-driven metabolomic approaches. Altered levels of [lyso]glycerophospholipids was the most specific metabolic trait associated to morbid obesity, particularly lysophosphatidylcholines acylated with margaric, oleic and linoleic acids [lysoPC C17:0: R=-0.56, p=0.0003; lysoPC C18:1: R=-0.61, p=0.0001; lysoPC C18:2 R=-0.64, penAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/mass spectrometrymetabolic markersobesityobservational studyprediabetesAdultBiomarkersDiabetes Mellitus, Type 2FemaleHumansMaleMetabolomicsMiddle AgedObesity, MorbidPhenotypePrediabetic Stateresearch article27720726open access10.1016/j.cca.2016.10.0051873-3492http://diposit.ub.edu/dspace/bitstream/2445/164099/1/664841.pdf