Villasanta-Gonzalez, AlejandroAlcala-Diaz, Juan FranciscoVals-Delgado, CristinaArenas, Antonio PabloCardelo, Magdalena PRomero-Cabrera, Juan LuisRodriguez-Cantalejo, FernandoDelgado-Lista, JavierMalagon, Maria MPerez-Martinez, PabloSchulze, Matthias BCamargo, AntonioLopez-Miranda, Jose2023-05-032023-05-032021-06-24Villasanta-Gonzalez A, Alcala-Diaz JF, Vals-Delgado C, Arenas AP, Cardelo MP, Romero-Cabrera JL, et al. A plasma fatty acid profile associated to type 2 diabetes development: from the CORDIOPREV study. Eur J Nutr. 2022 Mar;61(2):843-857http://hdl.handle.net/10668/19864The prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide. For this reason, it is essential to identify biomarkers for the early detection of T2DM risk and/or for a better prognosis of T2DM. We aimed to identify a plasma fatty acid (FA) profile associated with T2DM development. We included 462 coronary heart disease patients from the CORDIOPREV study without T2DM at baseline. Of these, 107 patients developed T2DM according to the American Diabetes Association (ADA) diagnosis criteria after a median follow-up of 60 months. We performed a random classification of patients in a training set, used to build a FA Score, and a Validation set, in which we tested the FA Score. FA selection with the highest prediction power was performed by random survival forest in the Training set, which yielded 4 out of the 24 FA: myristic, petroselinic, α-linolenic and arachidonic acids. We built a FA Score with the selected FA and observed that patients with a higher score presented a greater risk of T2DM development, with an HR of 3.15 (95% CI 2.04-3.37) in the Training set, and an HR of 2.14 (95% CI 1.50-2.84) in the Validation set, per standard deviation (SD) increase. Moreover, patients with a higher FA Score presented lower insulin sensitivity and higher hepatic insulin resistance (p  Our results suggest that a detrimental FA plasma profile precedes the development of T2DM in patients with coronary heart disease, and that this FA profile can, therefore, be used as a predictive biomarker.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/COXDisease predictionFA ScoreFatty acidsType 2 diabetesBiomarkersCoronary diseaseDiabetes mellitus, type 2Fatty acidsHumansInsulin resistanceresearch article34609622open accessBiomarcadoresDiabetes mellitus tipo 2Enfermedad coronariaResistencia a la insulinaÁcidos grasos10.1007/s00394-021-02676-z1436-6215PMC8854256https://link.springer.com/content/pdf/10.1007/s00394-021-02676-z.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854256/pdf