Mateos-Olivares, MSobas, E MPuertas-Neyra, KPeralta-Ramirez, M IGonzalez-Perez, RMartin-Vallejo, JGarcia-Vazquez, CCoco, R MPastor, J CPastor-Idoate, SUsategui-Martin, R2023-05-032023-05-032022-02-25Mateos-Olivares M, Sobas EM, Puertas-Neyra K, Peralta-Ramírez MI, González-Pérez R, Martín-Vallejo J, et al. Hair cortisol level as a molecular biomarker in retinitis pigmentosa patients. Exp Eye Res. 2022 Jun;219:109019.http://hdl.handle.net/10668/22225Retinitis pigmentosa (RP) patients commonly experience negative psychological states due to their progressive and unpredictable loss of vision and visual variations related to stress. The aim of this study was to examine hair cortisol concentrations (HCCs), which is usually associated with chronic stress, pretending to unveil possible associations between underlying psychological factors and disease severity in RP patients. Seventy-eight RP patients and 148 healthy controls were included in this study. A complete ophthalmological exam was performed in all patients to grade into severity disease groups. Perceived stress and trait-anxiety were measured by the State-Trait Anxiety Inventory (STAI) questionnaire. Fifty-two (67%) patients had severe RP and 26 (33%) mild-moderate RP. Fifty-eight (58,9%) patients reported severely levels of stress and 18 (23.,1%) highly levels assessed by STAI questionnaire. RP patients exhibited higher HCCs (500.04 ± 120.99 pg/mg) than in controls (136.17 ± 60.51 pg/mg; p  HCC seems an effective biomarker associated with chronic stress in RP patients. This study shows that HCC in patients with RP are elevated compared to population-based controls, and association between HCC and RP severity was found. Future research is needed to characterize the effect of untreated negative psychological states on progression of the disease if any.enAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Chronic stressHair cortisol concentrationNegative psychological statesRetinitis pigmentosaVariations in visionBiomarkersHairHumansHydrocortisoneRetinitis PigmentosaSurveys and Questionnairesresearch article35263654open accessBiomarcadoresCabelloEncuestas y cuestionariosHidrocortisonaHumanosRetinitis pigmentosa10.1016/j.exer.2022.1090191096-0007https://doi.org/10.1016/j.exer.2022.109019