Rodriguez-Gil, AlfonsoCarrillo-Cruz, EstrellaMarrero-Cepeda, CristinaRodriguez, GuillermoPerez-Simon, Jose A2023-05-032023-05-032022-04-24Rodríguez-Gil A, Carrillo-Cruz E, Marrero-Cepeda C, Rodríguez G, Pérez-Simón JA. Effect of Vitamin D on Graft-versus-Host Disease. Biomedicines. 2022 Apr 24;10(5):987.2227-9059http://hdl.handle.net/10668/20827The different cell subsets of the immune system express the vitamin D receptor (VDR). Through the VDR, vitamin D exerts different functions that influence immune responses, as previously shown in different preclinical models. Based on this background, retrospective studies explored the impacts of vitamin D levels on the outcomes of patients undergoing allogeneic hematopoietic stem-cell transplantation, showing that vitamin D deficiency is related to an increased risk of complications, especially graft-versus-host disease. These results were confirmed in a prospective cohort trial, although further studies are required to confirm this data. In addition, the role of vitamin D on the treatment of hematologic malignancies was also explored. Considering this dual effect on both the immune systems and tumor cells of patients with hematologic malignancies, vitamin D might be useful in this setting to decrease both graft-versus-host disease and relapse rates.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/calcifediolcalcitriolgraft-versus-host diseasevitamin Dvitamin D receptor (VDR)Receptors, CalcitriolProspective StudiesRetrospective StudiesVitaminsVitamin D DeficiencyHematopoietic Stem Cell TransplantationHematologic NeoplasmsImmune SystemImmunityReview35625724open accessCélulasNeoplasias HematológicasEnfermedad injerto contra huéspedSistema InmunológicoRecurrenciaNeoplasiasDeficiencia de vitamina DInmunidadReceptores de Calcitriol10.3390/biomedicines10050987PMC9138416https://www.mdpi.com/2227-9059/10/5/987/pdf?version=1653023825https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138416/pdf