Ruano, JuanSuarez-Fariñas, MayteShemer, AvnerOliva, MargeauxGuttman-Yassky, EmmaKrueger, James G2023-01-252023-01-252016-01-18Ruano J, Suárez-Fariñas M, Shemer A, Oliva M, Guttman-Yassky E, Krueger JG. Molecular and Cellular Profiling of Scalp Psoriasis Reveals Differences and Similarities Compared to Skin Psoriasis. PLoS One. 2016 Feb 5;11(2):e0148450http://hdl.handle.net/10668/9814Scalp psoriasis shows a variable clinical spectrum and in many cases poses a great therapeutic challenge. However, it remains unknown whether the immune response of scalp psoriasis differs from understood pathomechanisms of psoriasis in other skin areas. We sought to determine the cellular and molecular phenotype of scalp psoriasis by performing a comparative analysis of scalp and skin using lesional and nonlesional samples from 20 Caucasian subjects with untreated moderate to severe psoriasis and significant scalp involvement and 10 control subjects without psoriasis. Our results suggest that even in the scalp, psoriasis is a disease of the inter-follicular skin. The immune mechanisms that mediate scalp psoriasis were found to be similar to those involved in skin psoriasis. However, the magnitude of dysregulation, number of differentially expressed genes, and enrichment of the psoriatic genomic fingerprint were more prominent in skin lesions. Furthermore, the scalp transcriptome showed increased modulation of several gene-sets, particularly those induced by interferon-gamma, compared with that of skin psoriasis, which was mainly associated with activation of TNFα/L-17/IL-22-induced keratinocyte response genes. We also detected differences in expression of gene-sets involving negative regulation, epigenetic regulation, epidermal differentiation, and dendritic cell or Th1/Th17/Th22-related T-cell processes.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/AdultCase-control studiesCytokinesDendritic cellsEpigenesis, geneticFemaleGene expression profilingHumansKeratinocytesMaleMiddle agedPsoriasisScalpSkinT-lymphocytesTh1 cellsTh17 cellsTranscriptomeresearch article26849645open accessCuero cabelludoCélulas TH1Células Th17Linfocitos TPerfilación de la expresión génicaPielPsoriasisQueratinocitosTranscriptoma10.1371/journal.pone.01484501932-6203PMC4743842https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0148450&type=printablehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743842/pdf