Santos García, DDe Deus Fonticoba, TPaz González, J MCores Bartolomé, CValdés Aymerich, LMuñoz Enríquez, J GSuárez, EJesús, SAguilar, MPastor, PPlanellas, L LCosgaya, MGarcía Caldentey, JCaballol, NLegarda, IHernández Vara, JCabo, ILópez Manzanares, LGonzález Aramburu, IÁvila Rivera, M ACatalán, M JNogueira, VPuente, VGarcía Moreno, J MBorrué, CSolano Vila, BÁlvarez Sauco, MVela, LEscalante, SCubo, ECarrillo Padilla, FMartínez Castrillo, J CSánchez Alonso, PAlonso Losada, M GLópez Ariztegui, NGastón, IKulisevsky, JBlázquez Estrada, MSeijo, MRúiz Martínez, JValero, CKurtis, Mde Fábregues, OGonzález Ardura, JOrdás, CLópez Díaz, LMir, PMartinez-Martin, PCoppadis Study Group,2025-01-072025-01-072021-05-132090-8083https://hdl.handle.net/10668/27762In a degenerative disorder such as Parkinson's disease (PD), it is important to establish clinical stages that allow to know the course of the disease. Our aim was to analyze whether a scale combining Hoehn and Yahr's motor stage (H&Y) and the nonmotor symptoms burden (NMSB) (assessed by the nonmotor symptoms scale (NMSS)) provides information about the disability and the patient's quality of life (QoL) with regard to a defined clinical stage. Cross-sectional study in which 603 PD patients from the COPPADIS cohort were classified according to H&Y (1, stage I; 2, stage II; 3, stage III; 4, stage IV/V) and NMSB (A: NMSS = 0-20; B: NMSS = 21-40; C: NMSS = 41-70; D: NMSS ≥ 71) in 16 stages (HY.NMSB, from 1A to 4D). QoL was assessed with the PDQ-39SI, PQ-10, and EUROHIS-QOL8 and disability with the Schwab&England ADL (Activities of Daily Living) scale. A worse QoL and greater disability were observed at a higher stage of H&Y and NMSB (p The HY.NMSB scale is simple and reflects the degree of patient involvement more accurately than the H&Y. Patients with a lower H&Y stage may be more affected if they have a greater NMS burden.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/research article34094501open access10.1155/2021/8871549PMC8140853https://downloads.hindawi.com/journals/pd/2021/8871549.pdfhttps://pmc.ncbi.nlm.nih.gov/articles/PMC8140853/pdf