Gutierrez-Gutierrez, BelenPerez-Nadales, ElenaRodriguez-Baño, JesusTorre-Cisneros, Julian2023-02-082023-02-082020-04-12Gutiérrez-Gutiérrez B, Pérez-Nadales E, Rodríguez-Baño J, Torre-Cisneros J. Reply to "CMV merits further evolutionary and biological view". Am J Transplant. 2020 May;20(5):1467-1468http://hdl.handle.net/10668/15257We thank Ferhat Arslan for this letter. Biological significance is certainly the most important aspect in biomedical research; however, statistics provide a powerful tool to reveal associations between biological variables. In our study, we aimed to identify predictor variables for mortality in solid organ transplant recipients with carbapenemase-producing Enterobacteriaceae-bloodstream infections (CPE-BSI) regardless of their causal associations and to analyze the predictive capacity of the model. However, in this case, we consider there is a plausible clinical justification for the variables and interaction obtained in our model. Thus, for the interaction term, it could be interpreted that in high-risk patients, the mortality associated with CPE infection is so high that the impact of a previous cytomegalovirus (CMV) infection would not involve higher mortality.enAntibiotic drug resistanceClinical research/practiceInfection and infectious agents-bacterialInfectious diseaseBacterial proteinsCytomegalovirusCytomegalovirus infectionsHumansLymphopeniaTransplant recipientsbeta-Lactamasesresearch article32185864open accessCitomegalovirusInfecciones por citomegalovirusLinfopeniaProteínas bacterianasReceptores de trasplantes10.1111/ajt.158671600-6143https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ajt.15867