Cobo-Dols, ManuelBeato-Zambrano, CarmenCabezon-Gutierrez, LuisChicas-Sett, RodolfoBlancas-Lopez-Barajas, Maria IsabelGarcia-Navalon, FranciscoFirvida-Perez, Jose LuisSerrano-Bermudez, GalaTogores-Torres, PilarDelgado-Mingorance, IgnacioGiraldo-Marin, AlexandraLibran-Oriol, AnnaParedes-Lario, AlfredoSanchez-Mauriño, PedroHiguera-Gomez, OliverMoreno-Muñoz, DianaJimenez-Lopez, Antonio JavierHuerta-Gonzalez, IboneSanz-Yague, AlmudenaSoler-Lopez, Begoña2023-02-082023-02-082020-05-06Cobo Dols M, Beato Zambrano C, Cabezón Gutiérrez L, Chicas Sett R, Blancas López-Barajas MI, García Navalón F, et al. Efficacy of naloxegol on symptoms and quality of life related to opioid-induced constipation in patients with cancer: a 3-month follow-up analysis. BMJ Support Palliat Care. 2021 Mar;11(1):25-31http://hdl.handle.net/10668/15521Opioid-induced constipation (OIC) can affect up to 63% of all patients with cancer. The objectives of this study were to assess quality of life as well as efficacy and safety of naloxegol, in patients with cancer with OIC. An observational study was made of a cohort of patients with cancer and with OIC exhibiting an inadequate response to laxatives and treated with naloxegol. The sample consisted of adult outpatients with a Karnofsky performance status score ≥50. The Patient Assessment of Constipation Quality of Life Questionnaire (PAC-QOL) and the Patient Assessment of Constipation Symptoms (PAC-SYM) were applied for 3 months. A total of 126 patients (58.2% males) with a mean age of 61.3 years (range 34-89) were included. Clinically relevant improvements (>0.5 points) were recorded in the PAC-QOL and PAC-SYM questionnaires (p0.5 points) were recorded in the PAC-QOL and PAC-SYM questionnaires (p Clinically relevant improvements in OIC-related quality of life, number of bowel movements and constipation-related symptoms were recorded as early as after 15 days of treatment with naloxegol in patients with cancer and OIC, with a good safety profile.enAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/CancerConstipationPainQuality of lifeAdultAgedAged, 80 and overAnalgesics, OpioidCancer PainCohort StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedMorphinansNarcotic AntagonistsOpioid-Induced ConstipationPain ManagementPatient Reported Outcome MeasuresPolyethylene GlycolsQuality of LifeSurveys and Questionnairesresearch article32376758open accessNeoplasiasCalidad de VidaEstreñimientoLaxativosEstado de Ejecución de KarnofskyEstreñimiento Inducido por Opioides10.1136/bmjspcare-2020-0022492045-4368PMC7907572https://spcare.bmj.com/content/bmjspcare/11/1/25.full.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907572/pdf