Santos-Marcos, Jose A.Barroso, AlexiaRangel-Zuñiga, Oriol A.Perdices-Lopez, CeciliaHaro, CarmenSanchez-Garrido, Miguel A.Molina-Abril, HelenaOhlsson, ClaesPerez-Martinez, PabloPoutanen, MattiLopez-Miranda, JosePerez-Jimenez, FranciscoTena-Sempere, ManuelCamargo, Antonio2022-09-022022-09-022020-10-27Santos-Marcos JA, Barroso A, Rangel-Zuñiga OA, Perdices-Lopez C, Haro C, Sanchez-Garrido MA, et al. Interplay between gonadal hormones and postnatal overfeeding in defining sex-dependent differences in gut microbiota architecture. Aging. 2020 Oct 27;12(20):19979-20000http://hdl.handle.net/10668/3981Aging is associated with a decline in sex hormones, variable between sexes, that has an impact on many different body systems and might contribute to age-related disease progression. We aimed to characterize the sex differences in gut microbiota, and to explore the impact of depletion of gonadal hormones, alone or combined with postnatal overfeeding, in rats. Many of the differences in the gut microbiota between sexes persisted after gonadectomy, but removal of gonadal hormones shaped several gut microbiota features towards a more deleterious profile, the effect being greater in females than in males, mainly when animals were concurrently overfed. Moreover, we identified several intestinal miRNAs as potential mediators of the impact of changes in gut microbiota on host organism physiology. Our study points out that gonadal hormones contribute to defining sex-dependent differences of gut microbiota, and discloses a potential role of gonadal hormones in shaping gut microbiota, as consequence of the interaction between sex and nutrition. Our data suggest that the changes in gut microbiota, observed in conditions of sex hormone decline, as those caused by ageing in men and menopause in women, might exert different effects on the host organism, which are putatively mediated by gut microbiota-intestinal miRNA cross-talk.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Gut microbiotaSex steroidsGenderMetabolismmiRNAsMicrobioma gastrointestinalIdentidad de géneroMetabolismoMicroARNsMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Animal Nutritional Physiological PhenomenaMedical Subject Headings::Organisms::Eukaryota::AnimalsMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::DysbiosisMedical Subject Headings::Check Tags::FemaleMedical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Gonadal HormonesMedical Subject Headings::Phenomena and Processes::Biological Phenomena::Biological Processes::Host-Pathogen InteractionsMedical Subject Headings::Anatomy::Digestive System::Gastrointestinal Tract::IntestinesMedical Subject Headings::Check Tags::MaleMedical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Antisense Elements (Genetics)::RNA, Antisense::MicroRNAsMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Nutritional StatusMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Endocrine Surgical Procedures::Castration::OrchiectomyMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Endocrine Surgical Procedures::Castration::OvariectomyMedical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::OvernutritionMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats::Rats, WistarMedical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Sex FactorsMedical Subject Headings::Phenomena and Processes::Microbiological Phenomena::Microbiotaresearch article33107844Acceso abierto10.18632/aging.1041401945-4589PMC7655199