Cruz-Lemini, MonicaFerriols Perez, Elenade la Cruz Conty, Maria LuisaCaño Aguilar, AfricaEncinas Pardilla, Maria BegoñaPrats Rodríguez, PilarMuner Hernando, MartaForcen Acebal, LauraPintado Recarte, PilarMedina Mallen, Maria Del CarmenPerez Perez, NoeliaCanet Rodriguez, JuditVillalba Yarza, AnaNieto Velasco, OlgaDel Barrio Fernandez, Pablo GuillermoOrizales Lago, Carmen MariaMarcos Puig, BeatrizMuñoz Abellana, BegoñaFuentes Ricoy, LauraRodriguez Vicente, AguedaJaneiro Freire, Maria JesusAlferez Alvarez-Mallo, MacarenaCasanova Pedraz, CristinaAlomar Mateu, OnofreLesmes Heredia, CristinaWizner de Alva, Juan CarlosPosadas San Juan, AlmaMacia Badia, MontserratAlvarez Colomo, CristinaSanchez Muñoz, AntonioPratcorona Alicart, LaiaAlonso Saiz, RubenLopez Rodriguez, MonicaBarbancho Lopez, Maria CarmenMeca Casbas, Marta RuthVaquerizo Ruiz, OscarMoran Antolin, EvaNuñez Valera, Maria JoseFernandez Fernandez, CaminoTubau Navarra, AlbertCano Garcia, Alejandra MariaSoldevilla Perez, SusanaGattaca Abasolo, IreneAdanez Garcia, JosePuertas Prieto, AlbertoOstos Serna, RosaGuadix Martin, Maria Del PilarCatalina Coello, MonicaEspuelas Malon, SilviaSainz Bueno, Jose AntonioGranell Escobar, Maria ReyesCruz Melguizo, SaraMartinez Perez, OscarOn Behalf Of The Spanish Obstetric Emergency Group,2023-02-092023-02-092021-01-15http://hdl.handle.net/10668/17004Around two percent of asymptomatic women in labor test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Spain. Families and care providers face childbirth with uncertainty. We determined if SARS-CoV-2 infection at delivery among asymptomatic mothers had different obstetric outcomes compared to negative patients. This was a multicenter prospective study based on universal antenatal screening for SARS-CoV-2 infection. A total of 42 hospitals tested women admitted for delivery using polymerase chain reaction, from March to May 2020. We included positive mothers and a sample of negative mothers asymptomatic throughout the antenatal period, with 6-week postpartum follow-up. Association between SARS-CoV-2 and obstetric outcomes was evaluated by multivariate logistic regression analyses. In total, 174 asymptomatic SARS-CoV-2 positive pregnancies were compared with 430 asymptomatic negative pregnancies. No differences were observed between both groups in key maternal and neonatal outcomes at delivery and follow-up, with the exception of prelabor rupture of membranes at term (adjusted odds ratio 1.88, 95% confidence interval 1.13-3.11; p = 0.015). Asymptomatic SARS-CoV-2 positive mothers have higher odds of prelabor rupture of membranes at term, without an increase in perinatal complications, compared to negative mothers. Pregnant women testing positive for SARS-CoV-2 at admission for delivery should be reassured by their healthcare workers in the absence of symptoms.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/SARS-CoV-2asymptomatic infectioncoronavirusdeliverymaternal complicationsperinatal outcomespregnancyAdolescentAdultAsymptomatic InfectionsCOVID-19FemaleHumansInfant, NewbornMiddle AgedMultivariate AnalysisPregnancyPregnancy Complications, InfectiousPregnancy OutcomePregnant WomenProspective StudiesSARS-CoV-2SpainYoung Adultresearch article33467629open access10.3390/v130101121999-4915PMC7830626https://www.mdpi.com/1999-4915/13/1/112/pdf?version=1610715978https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830626/pdf