Sanikini, HarinakshiMuller, David CSophiea, MarisaRinaldi, SabinaAgudo, AntonioDuell, Eric JWeiderpass, ElisabeteOvervad, KimTjønneland, AnneHalkjaer, JytteBoutron-Ruault, Marie-ChristineCarbonnel, FranckCervenka, IrisBoeing, HeinerKaaks, RudolfKühn, TilmanTrichopoulou, AntoniaMartimianaki, GeorgiaKarakatsani, AnnaPala, ValeriaPalli, DomenicoMattiello, AmaliaTumino, RosarioSacerdote, CarlottaSkeie, GuriRylander, CharlottaChirlaque Lopez, Maria-DoloresSanchez-Perez, Maria-JoseArdanaz, EvaRegner, SaraStocks, TanjaBueno-de-Mesquita, BasVermeulen, Roel C HAune, DagfinnTong, Tammy Y NKliemann, NathalieMurphy, NeilChadeau-Hyam, MarcGunter, Marc JCross, Amanda J2023-01-252023-01-252019-03-28Sanikini H, Muller DC, Sophiea M, Rinaldi S, Agudo A, Duell EJ, et al. Anthropometric and reproductive factors and risk of esophageal and gastric cancer by subtype and subsite: Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Int J Cancer. 2020 Feb 15;146(4):929-942.http://hdl.handle.net/10668/13905Obesity has been associated with upper gastrointestinal cancers; however, there are limited prospective data on associations by subtype/subsite. Obesity can impact hormonal factors, which have been hypothesized to play a role in these cancers. We investigated anthropometric and reproductive factors in relation to esophageal and gastric cancer by subtype and subsite for 476,160 participants from the European Prospective Investigation into Cancer and Nutrition cohort. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox models. During a mean follow-up of 14 years, 220 esophageal adenocarcinomas (EA), 195 esophageal squamous cell carcinomas, 243 gastric cardia (GC) and 373 gastric noncardia (GNC) cancers were diagnosed. Body mass index (BMI) was associated with EA in men (BMI ≥30 vs. 18.5-25 kg/m2 : HR = 1.94, 95% CI: 1.25-3.03) and women (HR = 2.66, 95% CI: 1.15-6.19); however, adjustment for waist-to-hip ratio (WHR) attenuated these associations. After mutual adjustment for BMI and HC, respectively, WHR and waist circumference (WC) were associated with EA in men (HR = 3.47, 95% CI: 1.99-6.06 for WHR >0.96 vs. 0.96 vs. 98 vs. 0.82 vs. 84 vs. 2 vs. 0) and age at first pregnancy and GNC (HR = 0.54, 95% CI: 0.32-0.91; >26 vs. 26 vs.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/canceresophagealgastrichormonesobesityreproductiveAnthropometryBody Fat DistributionCohort StudiesEsophageal NeoplasmsEuropeFemaleHumansMaleMiddle AgedProportional Hazards ModelsProspective StudiesReproductive HistoryRisk FactorsStomach Neoplasmsresearch article31050823open accessAntropometríaDistribución de la grasa corporalHistoria reproductivaFemeninoFactores de riesgoHumanosHistoria reproductivaPersona de mediana edadNeoplasias gástricasNeoplasias esofágicasModelos de riesgos proporcionales10.1002/ijc.323861097-0215PMC6973006https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.32386https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973006/pdf