Jakobsen, Marianne U.Dethlefsen, ClausDue, Karen M.Slimani, NadiaChajès, VeroniqueMay, Anne M.Sørensen, Thorkild I A.Halkjær, JytteTjønneland, AnneClavel-Chapelon, FrancoiseBoutron-Ruault, Marie-ChristineFagherazzi, GuyTeucher, BirgitKaaks, RudolfBoeing, HeinerSchütze, MadlenTrichopoulou, AntoniaZylis, DimosthenisMakrygiannis, GeorgePalli, DomenicoMattiello, AmaliaTagliabue, Giovannavan der A, Daphne L.Bueno-de-Mesquita, H BRodríguez, LaudinaTravier, NoémieMolina-Montes, EstherHuerta, José M.Barricarte, AurelioAmiano, PilarManjer, JonasWirfält, ElisabetJohansson, IngegerdHallmans, GöranKhaw, Kay-TeeWareham, Nicholas J.Crowe, FrancescaRomieu, IsabelleRiboli, ElioPeeters, Petra H MOvervad, Kim2015-09-282015-09-282011-08-01Jakobsen MU, Dethlefsen C, Due KM, Slimani N, Chajès V, May AM, et al. Plasma phospholipid long-chain n-3 polyunsaturated fatty acids and body weight change. Obes Facts 2011; 4(4):312-81662-4025http://hdl.handle.net/10668/1999Journal Article; Research Support, Non-U.S. Gov't;OBJECTIVE We investigated the association between the proportion of long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma phospholipids from blood samples drawn at enrollment and subsequent change in body weight. Sex, age, and BMI were considered as potential effect modifiers. METHOD A total of 1,998 women and men participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) were followed for a median of 4.9 years. The associations between the proportion of plasma phospholipid long-chain n-3 PUFA and change in weight were investigated using mixed-effect linear regression. RESULTS The proportion of long-chain n-3 PUFA was not associated with change in weight. Among all participants, the 1-year weight change was -0.7 g per 1% point higher long-chain n-3 PUFA level (95% confidence interval: -20.7 to 19.3). The results when stratified by sex, age, or BMI groups were not systematically different. CONCLUSION The results of this study suggest that the proportion of long-chain n-3 PUFA in plasma phospholipids is not associated with subsequent change in body weight within the range of exposure in the general population.enBody weightCohort studyn-3 fatty acidsOmega-3 fatty acidsWeight changeÁcidos grasos omega-3FemeninoHumanosModelos linealesMasculinoMediana edadObesidadFosfolípidosEstudios prospectivosPeso corporalMedical Subject Headings::Chemicals and Drugs::Lipids::Fats::Dietary Fats::Dietary Fats, Unsaturated::Fatty Acids, Omega-3Medical Subject Headings::Check Tags::FemaleMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Linear ModelsMedical Subject Headings::Check Tags::MaleMedical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle AgedMedical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::ObesityMedical Subject Headings::Chemicals and Drugs::Lipids::PhospholipidsMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective StudiesMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Weightresearch article21921655open access10.1159/0003307101662-4033