Razquin, CristinaRuiz-Canela, MiguelToledo, EstefaniaHernandez-Alonso, PabloClish, Clary B.Guasch-Ferre, MartaLi, JunWittenbecher, ClemensDennis, CourtneyAlonso-Gomez, AngelFito, MontseLiang, LimingCorella, DoloresGomez-Gracia, EnriqueEstruch, RamonFiol, MiquelLapetra, JoseSerra-Majem, LluisRos, EmilioAros, FernandoSalas-Salvado, JordiHu, Frank B.Martinez-Gonzalez, Miguel A.2025-01-072025-01-072021-07-220002-9165https://hdl.handle.net/10668/26963Background: The tryptophan-kynurenine pathway is linked to inflammation. We hypothesize that metabolites implicated in this pathway may be associated with the risk of heart failure (HF) or atrial fibrillation (AF) in a population at high risk of cardiovascular disease.Objectives: We aimed to prospectively analyze the associations of kynurenine-related metabolites with the risk of HF and AF and to analyze a potential effect modification by the randomized interventions of the PREDIMED (Prevencion con Dieta MediterrAnea) trial with Mediterranean diet (MedDiet).Methods: Two case-control studies nested within the PREDIMED trial were designed. We selected 324 incident HF cases and 502 incident AF cases individually matched withentryptophankynurenineheart failureatrial fibrillationmetabolomicsMediterranean dietcase-controlPREDIMEDCardiovascular-diseaseOlive oilInflammationBiomarkersPredictorsCancerAdultsresearch article34291275open access10.1093/ajcn/nqab2381938-3207https://doi.org/10.1093/ajcn/nqab238739392700010