Perán, MacarenaGarcía, María ALópez-Ruiz, ElenaBustamante, MilánJiménez, GemaMadeddu, RobertoMarchal, Juan A2012-11-232012-11-232012-03-22Perán M, García MA, López-Ruiz E, Bustamante M, Jiménez G, Madeddu R et al. Functionalized nanostructures with application in regenerative medicine.Int J Mol Sci. 2012;13(3):3847-86.http://hdl.handle.net/10668/649In the last decade, both regenerative medicine and nanotechnology have been broadly developed leading important advances in biomedical research as well as in clinical practice. The manipulation on the molecular level and the use of several functionalized nanoscaled materials has application in various fields of regenerative medicine including tissue engineering, cell therapy, diagnosis and drug and gene delivery. The themes covered in this review include nanoparticle systems for tracking transplanted stem cells, self-assembling peptides, nanoparticles for gene delivery into stem cells and biomimetic scaffolds useful for 2D and 3D tissue cell cultures, transplantation and clinical application.enRegenerative medicineNanomaterialsScaffoldsCell therapyStem cellsBoneCartilageCell encapsulationCell trackingGene and drug deliveryNanoestructurasAndamios del TejidoIngeniería de TejidosRegeneración ÓseaCartílagoMedicina RegenerativaNanopartículasSistemas de Liberación de MedicamentosCélulas Madre PluripotentesTécnicas de Transferencia de GenMedical Subject Headings::Technology, Industry, Agriculture::Technology, Industry, and Agriculture::Manufactured Materials::NanostructuresMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Equipment and Supplies::Culture Media::Tissue ScaffoldsMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Culture Techniques::Cell Engineering::Tissue EngineeringMedical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Bone Remodeling::Bone RegenerationMedical Subject Headings::Anatomy::Tissues::Connective Tissue::CartilageMedical Subject Headings::Disciplines and Occupations::Health Occupations::Medicine::Regenerative MedicineMedical Subject Headings::Technology, Industry, Agriculture::Technology, Industry, and Agriculture::Manufactured Materials::Nanostructures::NanoparticlesMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Delivery SystemsMedical Subject Headings::Anatomy::Cells::Stem Cells::Pluripotent Stem CellsMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Gene Transfer Techniquesresearch article22489186open access10.3390/ijms130338471422-0067PMC3317746