Fehringer, GordonKraft, PeterPharoah, Paul DEeles, Rosalind AChatterjee, NilanjanSchumacher, Fredrick RSchildkraut, Joellen MLindström, SaraBrennan, PaulBickeböller, HeikeHoulston, Richard SLandi, Maria TeresaCaporaso, NeilRisch, AngelaAmin Al Olama, AliBerndt, Sonja IGiovannucci, Edward LGrönberg, HenrikKote-Jarai, ZsofiaMa, JingMuir, KennethStampfer, Meir JStevens, Victoria LWiklund, FredrikWillett, Walter CGoode, Ellen LPermuth, Jennifer BRisch, Harvey AReid, Brett MBezieau, StephaneBrenner, HermannChan, Andrew TChang-Claude, JennyHudson, Thomas JKocarnik, Jonathan KNewcomb, Polly ASchoen, Robert ESlattery, Martha LWhite, EmilyAdank, Muriel AAhsan, HabibulAittomäki, KristiinaBaglietto, LauraBlomquist, CarlCanzian, FedericoCzene, KamilaDos-Santos-Silva, IsabelEliassen, A HeatherFigueroa, Jonine DFlesch-Janys, DieterFletcher, OliviaGarcia-Closas, MontserratGaudet, Mia MJohnson, NicholaHall, PerHazra, AditiHein, RebeccaHofman, AlbertHopper, John LIrwanto, AstridJohansson, MattiasKaaks, RudolfKibriya, Muhammad GLichtner, PeterLiu, JianjunLund, EilivMakalic, EnesMeindl, AlfonsMüller-Myhsok, BertramMuranen, Taru ANevanlinna, HeliPeeters, Petra HPeto, JulianPrentice, Ross LRahman, NazneenSanchez-Perez, Maria-JoseSchmidt, Daniel FSchmutzler, Rita KSouthey, Melissa CTamimi, RullaTravis, Ruth CTurnbull, ClareUitterlinden, Andre GWang, ZhaomingWhittemore, Alice SYang, Xiaohong RZheng, WeiBuchanan, Daniel DCasey, GrahamConti, David VEdlund, Christopher KGallinger, StevenHaile, Robert WJenkins, MarkLe Marchand, LoïcLi, LiLindor, Noralene MSchmit, Stephanie LThibodeau, Stephen NWoods, Michael ORafnar, ThorunnGudmundsson, JuliusStacey, Simon NStefansson, KariSulem, PatrickChen, Y AnnTyrer, Jonathan PChristiani, David CWei, YongyueShen, HongbingHu, ZhibinShu, Xiao-OuShiraishi, KouyaTakahashi, AtsushiBossé, YohanObeidat, Ma'enNickle, DavidTimens, WimFreedman, Matthew LLi, QiyuanSeminara, DanielaChanock, Stephen JGong, JianPeters, UlrikeGruber, Stephen BAmos, Christopher ISellers, Thomas AEaston, Douglas FHunter, David JHaiman, Christopher AHenderson, Brian EHung, Rayjean JOvarian Cancer Association Consortium (OCAC)PRACTICAL ConsortiumHereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON)Colorectal Transdisciplinary (CORECT) StudyAfrican American Breast Cancer Consortium (AABC) and African Ancestry Prostate Cancer Consortium (AAPC)2023-01-252023-01-252016-04-20http://hdl.handle.net/10668/10103Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with ADAM15/THBS3 gene expression in lung. We also identified a known breast cancer locus CASP8/ALS2CR12 associated with prostate cancer, a known cancer locus at CDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer, and confirmed the associations of a breast BRCA2 locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression. Cancer Res; 76(17); 5103-14. ©2016 AACR.enBreast NeoplasmsColorectal NeoplasmsFemaleGenome-Wide Association StudyGenotypeHumansLung NeoplasmsMaleOvarian NeoplasmsProstatic Neoplasmsresearch article27197191open access10.1158/0008-5472.CAN-15-29801538-7445PMC5010493https://europepmc.org/articles/pmc5010493?pdf=renderhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010493/pdf