Leuermann, JonasStamenkovic, VladimirRamirez-Priego, PatriciaSánchez-Postigo, AlejandroFernández-Gavela, AdriánChapman, Cole A.Bailey, Ryan C.Lechuga, Laura M.Perez-Inestrosa, EzequielCollado, DanielHalir, RobertMolina-Fernández, Íñigo2021-06-172021-06-172020-12-08Leuermann J, Stamenkovic V, Ramirez-Priego P, Sánchez-Postigo A, Fernández-Gavela A, Chapman CA, et al. Coherent silicon photonic interferometric biosensor with an inexpensive laser source for sensitive label-free immunoassays. Opt Lett. 2020 Dec 8;45(24):6595-6598.0146-9592http://hdl.handle.net/10668/3374Over the past two decades, integrated photonic sensors have been of major interest to the optical biosensor community due to their capability to detect low concentrations of molecules with label-free operation. Among these, interferometric sensors can be read-out with simple, fixed-wavelength laser sources and offer excellent detection limits but can suffer from sensitivity fading when not tuned to their quadrature point. Recently, coherently detected sensors were demonstrated as an attractive alternative to overcome this limitation. Here we show, for the first time, to the best of our knowledge, that this coherent scheme provides sub-nanogram per milliliter limits of detection in C-reactive protein immunoassays and that quasi-balanced optical arm lengths enable operation with inexpensive Fabry-Perot-type lasers sources at telecom wavelengths.spaPhotonsFotonesBiosensing techniquesTécnicas biosensiblesLasersRayos laserInterferometryInterferometríaC-Reactive ProteinProteína C-ReactivaLimit of detectionLímite de detecciónImmunoassayInmunoensayoMedical Subject Headings::Phenomena and Processes::Physical Phenomena::Optical Phenomena::Light::PhotonsMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Molecular Probe Techniques::Biosensing TechniquesMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Equipment and Supplies::Optical Devices::LasersMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::InterferometryMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Albumins::C-Reactive ProteinMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Immunologic Techniques::Immunoassayletter33325848Acceso abierto10.1364/OL.4116351539-4794