López-Mejías, RaquelGenre, FernandaSevilla Pérez, BelénCastañeda, SantosOrtego-Centeno, NorbertoLlorca, JavierUbilla, BegoñaRemuzgo-Martínez, SaraMijares, VerónicaPina, TrinitarioCalvo-Río, VanesaMárquez, AnaMiranda-Filloy, José ANavas Parejo, AntonioConde-Jaldón, MartaOrtiz-Fernández, LourdesArgila, DiegoAragües, MaximilianoRubio, EstebanLeón Luque, ManuelBlanco-Madrigal, Juan MaríaGalíndez-Aguirregoikoa, EvaGonzález Escribano, FranciscaOcejo-Vinyals, J GonzaloMartín, JavierBlanco, RicardoGonzález-Gay, Miguel A2017-05-032017-05-032015-04-14López-Mejías R, Genre F, Pérez BS, Castañeda S, Ortego-Centeno N, Llorca J, et al. Association of HLA-B*41:02 with Henoch-Schönlein Purpura (IgA Vasculitis) in Spanish individuals irrespective of the HLA-DRB1 status. Arthritis Res. Ther. 2015; 17:1021478-6354http://hdl.handle.net/10668/2625INTRODUCTION: A study was conducted to determine whether the human leukocyte antigen (HLA) B alleles are implicated in the susceptibility to Henoch-Schönlein purpura (HSP) in the largest series of Caucasian HSP patients ever assessed for genetic studies. METHODS: The study population was composed of 349 Spanish patients diagnosed with HSP fulfilling the American College of Rheumatology and the Michel et al. classification criteria, and 335 sex and ethnically matched controls. HLA-B phenotypes were determined by sequencing-based typing (SBT) and analyzed by chi-square or Fisher exact test. RESULTS: A statistically significant increase of HLA-B*41:02 allele in HSP patients when compared with controls was found (8.3% versus 1.5% respectively; P = 0.0001; OR (odds ratio) =5.76 [2.15-19.3]). These results remained statistically significant after adjusting for Bonferroni correction (P = 0.0028). An internal validation also confirmed the susceptibility effect on HSP associated with HLA-B*41:02 (OR = 5.70 [1.98-16.44]). Since a former study described an association between HLA-DRB1*01:03 and HSP susceptibility, we also evaluated the implication of HLA-B*41:02 independently of HLA-DRB1*01:03. Interestingly, the association remained statistically significant (P = 0.0004, OR = 4.97 [1.8-16.9]). No HLA-B association with specific HSP clinical features was found. CONCLUSIONS: Our study indicates that HLA-B*41:02 is associated with the susceptibility to HSP in Spanish patients irrespective of HLA-DRB1 status.enAdolescenteNiñoPreescolarFemeninoEstudios de seguimientoEstudios de asociación genéticaPredisposición genética a la enfermedadAntígenos HLA-BCadenas HLA-DRB1HumanosMasculinoPúrpura de Schoenlein-HenochAdulto jovenEspañaMedical Subject Headings::Persons::Persons::Age Groups::AdolescentMedical Subject Headings::Persons::Persons::Age Groups::ChildMedical Subject Headings::Persons::Persons::Age Groups::Child::Child, PreschoolMedical Subject Headings::Check Tags::FemaleMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up StudiesMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Genetic Association StudiesMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Susceptibility::Genetic Predisposition to DiseaseMedical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Antigens, Surface::Histocompatibility Antigens::HLA AntigensMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Membrane Glycoproteins::Histocompatibility Antigens Class II::HLA-D Antigens::HLA-DR Antigens::HLA-DR beta-Chains::HLA-DRB1 ChainsMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Check Tags::MaleMedical Subject Headings::Geographicals::Geographic Locations::Europe::SpainMedical Subject Headings::Diseases::Immune System Diseases::Hypersensitivity::Immune Complex Diseases::Purpura, Schoenlein-HenochMedical Subject Headings::Persons::Persons::Age Groups::Adult::Young Adultresearch article25889603open access10.1186/s13075-015-0622-51478-6362PMC4416391