Sola-Rodriguez, SergioVargas-Hitos, Jose AntonioGavilan-Carrera, BlancaRosales-Castillo, AntonioRios-Fernandez, RaquelSabio, Jose MarioSoriano-Maldonado, Alberto2025-01-072025-01-072021-10-141664-3224https://hdl.handle.net/10668/26139Aims Higher body mass and adiposity represent independent contributors to the systemic low-grade inflammatory state often observed in patients with systemic lupus erythematosus (SLE). This study assessed the role of physical fitness in the association of body mass and adiposity with inflammation in women with SLE.Methods A total of 77 women with SLE were included in this cross-sectional study. We obtained body mass index, waist-to-height ratio, and body fat percentage as indicators of body mass and adiposity. Inflammation was assessed through Serum levels of C-reactive protein, interleukin 6, and leptin. Cardiorespiratory fitness was assessed with the 6-minute walk test, range of motion with the back-scratch test, and muscular strength with handgrip dynamometry.Results Cardiorespiratory fitness attenuated the association of both body mass index and body fat percentage with interleukin 6 (all, PenAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/obesitysystemic low-grade inflammationcardiorespiratory fitnessrange of motionflexibilityautoimmune diseasesbody mass indexbody fat percentage (BF%)C-reactive proteinCardiorespiratory fitnessDisease-activityAll-causeObesityAssociationValidationPredictorMortalityCapacityresearch article34721392open access10.3389/fimmu.2021.729672https://www.frontiersin.org/articles/10.3389/fimmu.2021.729672/pdf713854700001