Gálvez-Ontiveros, YolandaPáez, SaraMonteagudo, CeliaRivas, Ana2022-04-262022-04-262020-04-21Gálvez-Ontiveros Y, Páez S, Monteagudo C, Rivas A. Endocrine Disruptors in Food: Impact on Gut Microbiota and Metabolic Diseases. Nutrients. 2020 Apr 21;12(4):1158http://hdl.handle.net/10668/3570Endocrine disruptors (EDCs) have been associated with the increased incidence of metabolic disorders. In this work, we conducted a systematic review of the literature in order to identify the current knowledge of the interactions between EDCs in food, the gut microbiota, and metabolic disorders in order to shed light on this complex triad. Exposure to EDCs induces a series of changes including microbial dysbiosis and the induction of xenobiotic pathways and associated genes, enzymes, and metabolites involved in EDC metabolism. The products and by-products released following the microbial metabolism of EDCs can be taken up by the host; therefore, changes in the composition of the microbiota and in the production of microbial metabolites could have a major impact on host metabolism and the development of diseases. The remediation of EDC-induced changes in the gut microbiota might represent an alternative course for the treatment and prevention of metabolic diseases.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Endocrine disruptersFoodGut microbiotaMetabolic diseasesAlimentosMicrobioma gastrointestinalEnfermedades metabólicasMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::DysbiosisMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Endocrine DisruptorsMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic DiseasesMedical Subject Headings::Technology and Food and Beverages::Technology, Industry, and Agriculture::Industry::Food Industry::Food Technology::Food AnalysisMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::DysbiosisMedical Subject Headings::Phenomena and Processes::Microbiological Phenomena::MicrobiotaEndocrine Disruptors in Food: Impact on Gut Microbiota and Metabolic Diseasesreview article32326280open access10.3390/nu120411582072-6643PMC7231259