Blanco-Rojo, RuthPerez-Martinez, PabloLopez-Moreno, JavierMartinez-Botas, JavierDelgado-Lista, Javiervan-Ommen, BenYubero-Serrano, ElenaCamargo, AntonioOrdovas, Jose MPerez-Jimenez, FranciscoGomez-Coronado, DiegoLopez-Miranda, Jose2023-01-252023-01-252017-09-13Blanco-Rojo R, Perez-Martinez P, Lopez-Moreno J, Martinez-Botas J, Delgado-Lista J, van-Ommen B, et al. HDL cholesterol efflux normalised to apoA-I is associated with future development of type 2 diabetes: from the CORDIOPREV trial. Sci Rep. 2017 Oct 2;7(1):12499http://hdl.handle.net/10668/11639This prospective study evaluated whether baseline cholesterol efflux is associated with future development of type 2 diabetes (T2DM) in cardiovascular patients. We measured cholesterol efflux in all CORDIOPREV study (NCT00924937) participants free of T2DM at baseline (n = 462) and assessed its relationship with T2DM incidence during a 4.5 years of follow-up. Cholesterol efflux was quantified by incubation of cholesterol-loaded THP-1 cells with the participants' apoB-depleted plasma. Disposition index was estimated as beta-cell function indicator. During follow-up 106 individuals progressed to T2DM. The cholesterol efflux/apoA-1 ratio was inversely associated with T2DM development independently of traditional risk factors (model-1, OR: 0.647, 95%CI: 0.495-0.846), and after additional adjustment for glycaemic parameters (model-2, OR: 0.670, 95%CI: 0.511-0.878). When cumulative incidence of diabetes was analysed by quartiles of cholesterol efflux/apoA-I, incidence of T2DM was reduced by 54% in subjects who were in the higher cholesterol efflux/apoA-I quartile compared to subjects in the lowest quartile (p = 0.018 and p = 0.042 for model-1 and 2). Moreover, participants who were in the higher cholesterol efflux/apoA-I presented significantly higher disposition index (β = 0.056, SE = 0.026; p = 0.035). In conclusion, HDL-cholesterol efflux normalised to apoA-I was inversely associated with T2DM development in cardiovascular patients. This association was independent of several T2DM risk factors, and may be related to a preserved beta-cell function.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Area under curveBiological transportBiomarkersBlood glucoseBody mass indexCholesterol, HDLAgedDiabetes mellitus, type 2FemaleGlycated hemoglobinHumansHyperlipidemiasHypertensionInsulinInsulin resistanceLogistic modelsMaleMiddle agedPrognosisProspective studiesRisk factorsTHP-1 cellsWaist circumferenceApolipoprotein A-Iresearch article28970513open accessCircunferencia de la cinturaDiabetes mellitus tipo 2Estudios prospectivosFactores de riesgoHemoglobina glucadaHiperlipidemiasHipertensiónInsulinaResistencia a la insulina10.1038/s41598-017-12678-92045-2322PMC5624929https://www.nature.com/articles/s41598-017-12678-9.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624929/pdf