Martin-Broto, JavierHindi, NadiaCruz, JosefinaMartinez-Trufero, JavierValverde, ClaudiaDe Sande, Luis MSala, AngelesBellido, LorenaDe Juan, AnaRubió-Casadevall, JordiDiaz-Beveridge, RobertoCubedo, RicardoTendero, OscarSalinas, DiegoGracia, IsidroRamos, RafaelBaguè, SilviaGutierrez, AntonioDuran-Moreno, JoséLopez-Pousa, Antonio2023-01-252023-01-252018-11-08http://hdl.handle.net/10668/13162Reference centers (RCs) are a key point for improving the survival of patients with soft-tissue sarcomas (STS). The aim of this study was to evaluate selected items in the management of patients with STS, comparing results between RC and local hospitals (LHs). Diagnostic and therapeutic data from patients diagnosed between January 2004 and December 2011 were collected. Correlation with outcome was performed. A total of 622 sarcomas were analyzed, with a median follow-up of 40 months. Imaging of primary tumor preoperatively (yes vs. no) correlated with a higher probability of free surgical margins (77.4% versus 53.7%; p = .006). The provenance of the biopsy (RC vs. LH) significantly affected relapse-free survival (RFS; 3-year RFS 66% vs. 46%, respectively; p = .019). Likewise, 3-year RFS was significantly worse in cases with infiltrated (55.6%) or unknown (43.4%) microscopic surgical margins compared with free margins (63.6%; p Our series indicate that selected quality-of-care items were accomplished better by RCs over LHs, all with significant prognostic value in patients with STS. Early referral to an RC should be mandatory if the aim is to improve the survival of patients with STS. This prospective study in patients diagnosed with soft-tissue sarcoma shows the prognostic impact of reference centers in the management of these patients. The magnitude of this impact encompasses all steps of the process, from the initial management (performing diagnostic biopsy) to the advanced disease setting. This is the first prospective evidence showing improvement in outcomes of patients with metastatic disease when they are managed in centers with expertise. This study provides extra data supporting referral of patients with sarcoma to reference centers.enDiagnostic processMultidisciplinary managementOutcomeReference centersSarcomaBiopsyCancer Care FacilitiesDisease-Free SurvivalFemaleFollow-Up StudiesHumansMaleMargins of ExcisionMiddle AgedNeoplasm Recurrence, LocalPrognosisProspective StudiesReferral and ConsultationRegistriesSarcomaSpainTime Factorsresearch article30409793open access10.1634/theoncologist.2018-01211549-490XPMC6656480https://europepmc.org/articles/pmc6656480?pdf=renderhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656480/pdf