Lopes, Luis RLosi, Maria-AngelaSheikh, NabeelLaroche, CécileCharron, PhilippeGimeno, JuanKaski, Juan PMaggioni, Aldo PTavazzi, LuigiArbustini, EloisaBrito, DulceCelutkiene, JelenaHagege, AlbertLinhart, AlesMogensen, JensGarcia-Pinilla, José ManuelRipoll-Vera, TomasSeggewiss, HubertVillacorta, EduardoCaforio, AlidaElliott, Perry MCardiomyopathy Registry Investigators Group2023-05-032023-05-032022http://hdl.handle.net/10668/19763The interaction between common cardiovascular risk factors (CVRF) and hypertrophic cardiomyopathy (HCM) is poorly studied. We sought to explore the relation between CVRF and the clinical characteristics of patients with HCM enrolled in the EURObservational Research Programme (EORP) Cardiomyopathy registry. 1739 patients with HCM were studied. The relation between hypertension (HT), diabetes (DM), body mass index (BMI), and clinical traits was analysed. Analyses were stratified according to the presence or absence of a pathogenic variant in a sarcomere gene. The prevalence of HT, DM, and obesity (Ob) was 37, 10, and 21%, respectively. HT, DM, and Ob were associated with older age (P Common CVRF are associated with a more severe HCM phenotype, suggesting a proactive management of CVRF should be promoted. An interaction between genotype and CVRF was observed for some traits.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Cardiovascular risk factorsDiabetesGenotypeHypertensionHypertrophic cardiomyopathyObesityFemaleHumansCardiovascular DiseasesRisk FactorsCardiomyopathy, HypertrophicCardiomyopathiesVentricular Dysfunction, LeftHypertensionObesityHeart Disease Risk Factorsresearch article35138368open access10.1093/ehjqcco/qcac0062058-1742PMC9745665https://academic.oup.com/ehjqcco/advance-article-pdf/doi/10.1093/ehjqcco/qcac006/43556795/qcac006.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745665/pdf