Gil-Cosano, Jose J.Ubago-Guisado, EstherSanchez-Perez, Maria-JoseOrtega-Acosta, Maria J.Mateos, Maria E.Benito-Bernal, Ana I.Llorente-Cantarero, Francisco J.Ortega, Francisco B.Ruiz, Jonatan R.Labayen, IdoiaMartinez-Vizcaino, VicenteVlachopoulos, DimitrisArroyo-Morales, ManuelMuñoz-Torres, Manuel.Pascual-Gázquez, Juan F.Vicho-González, Maria C.Gracia-Marco, Luis2022-07-132022-07-132020-10-08Gil-Cosano JJ, Ubago-Guisado E, Sánchez MJ, Ortega-Acosta MJ, Mateos ME, Benito-Bernal AI, et al. The effect of an online exercise programme on bone health in paediatric cancer survivors (iBoneFIT): study protocol of a multi-centre randomized controlled trial. BMC Public Health. 2020 Oct 8;20(1):1520http://hdl.handle.net/10668/3790Background: New approaches on paediatric cancer treatment aim to maintain long-term health. As a result of radiotherapy, chemotherapy or surgery, paediatric cancer survivors tend to suffer from any chronic health condition. Endocrine dysfunction represents one of the most common issues and affects bone health. Exercise is key for bone mass accrual during growth, specifically plyometric jump training. The iBoneFIT study will investigate the effect of a 9-month online exercise programme on bone health in paediatric cancer survivors. This study will also examine the effect of the intervention on body composition, physical fitness, physical activity, calcium intake, vitamin D, blood samples quality of life and mental health. Methods: A minimum of 116 participants aged 6 to 18 years will be randomized into an intervention (n = 58) or control group (n = 58). The intervention group will receive an online exercise programme and diet counselling on calcium and vitamin D. In addition, five behaviour change techniques and a gamification design will be implemented in order to increase the interest of this non-game programme. The control group will only receive diet counselling. Participants will be assessed on 3 occasions: 1) at baseline; 2) after the 9 months of the intervention; 3) 4 months following the intervention. The primary outcome will be determined by dual energy X-ray absorptiometry (DXA) and the hip structural analysis, trabecular bone score and 3D-DXA softwares. Secondary outcomes will include anthropometry, body composition, physical fitness, physical activity, calcium and vitamin D intake, blood samples, quality of life and mental health. Discussion: Whether a simple, feasible and short in duration exercise programme can improve bone health has not been examined in paediatric cancer survivors. This article describes the design, rationale and methods of a study intended to test the effect of a rigorous online exercise programme on bone health in paediatric cancer survivors. If successful, the iBoneFIT study will contribute to decrease chronic health conditions in this population and will have a positive impact in the society.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/TelemedicineCancerSurvivorBonePlyometric exercisePaediatricsQuality of lifeTelemedicinaNeoplasiasSobrevivientesHuesosEjercicio pliométricoPediatríaCalidad de vidaMedical Subject Headings::Persons::Persons::Age Groups::AdolescentMedical Subject Headings::Persons::Persons::Patients::SurvivorsMedical Subject Headings::Persons::Persons::Age Groups::ChildMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Physical Therapy Modalities::Exercise TherapyMedical Subject Headings::Check Tags::FemaleMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Check Tags::MaleMedical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Program EvaluationMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Methods::Research DesignMedical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Bone DensityMedical Subject Headings::Information Science::Information Science::Communications Media::Telecommunications::TelemedicineMedical Subject Headings::Diseases::NeoplasmsMedical Subject Headings::Anatomy::Musculoskeletal System::Skeleton::Bone and BonesMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Physical Therapy Modalities::Exercise Therapy::Plyometric ExerciseMedical Subject Headings::Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Quality of Liferesearch article33032564open access10.1186/s12889-020-09607-31471-2458PMC7545891