Obon-Santacana, MireiaRomaguera, DoraGracia-Lavedan, EstherMolinuevo, AmaiaMolina-Montes, EstherShivappa, NitinHebert, James RTardon, AdoninaCastaño-Vinyals, GemmaMoratalla, FerranGuino, ElisabetMarcos-Gragera, RafaelAzpiri, MikelGil, LeireOlmedo-Requena, RocioLozano-Lorca, MacarenaAlguacil, JuanFernandez-Villa, TaniaMartin, VicenteMolina, Antonio JEderra, MariaMoreno-Iribas, ConchiPerez, BeatrizAragones, NuriaCastello, AdelaHuerta, Jose MªDierssen-Sotos, TrinidadGomez-Acebo, InesMolina-Barcelo, AnaPollan, MarinaKogevinas, ManolisMoreno, VictorAmiano, Pilar2023-01-252023-01-252019-06-19Obón-Santacana M, Romaguera D, Gracia-Lavedan E, Molinuevo A, Molina-Montes E, Shivappa N, et al. Dietary Inflammatory Index, Dietary Non-Enzymatic Antioxidant Capacity, and Colorectal and Breast Cancer Risk (MCC-Spain Study). Nutrients. 2019 Jun 21;11(6):1406.http://hdl.handle.net/10668/14166Inflammation and antioxidant capacity have been associated with colorectal and breast cancer. We computed the dietary inflammatory index (DII®), and the total dietary non-enzymatic antioxidant capacity (NEAC) and associated them with colorectal and breast cancer risk in the population-based multi case-control study in Spain (MCC-Spain). We included 1852 colorectal cancer and 1567 breast cancer cases, and 3447 and 1486 population controls, respectively. DII score and NEAC were derived using data from a semi-quantitative validated food frequency questionnaire. Unconditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (95%CI) for energy-adjusted DII (E-DII), and a score combining E-DII and NEAC. E-DII was associated with colorectal cancer risk (OR = 1.93, highest quartile versus lowest, 95%CI:1.60-2.32; p-trend: 0.10). The combined score of high E-DII scores and low antioxidant values were associated with colorectal cancer risk (OR = 1.48, highest quartile versus lowest, 95%CI: 1.26-1.74; p-trend:enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/MCC-SpainNEACantioxidantsbreast cancercase-control studycolorectal cancerdietdietary inflammatory indexAntioxidantsBreast NeoplasmsCase-Control StudiesColorectal NeoplasmsDietFemaleHumansInflammationMaleOxidation-ReductionPrognosisProtective FactorsRisk AssessmentRisk FactorsSpainresearch article31234427open accessAntioxidantesDietaEspañaPronósticoOxidación-reducciónNeoplasias de la mamaNeoplasias colorrectalesMedición de riesgoInflamaciónFactores de riesgo10.3390/nu110614062072-6643PMC6628286https://www.mdpi.com/2072-6643/11/6/1406/pdf?version=1561530949https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628286/pdf