Montserrat-de la Paz, SergioLopez, SergioBermudez, BeatrizGuerrero, Juan MAbia, RocioMuriana, Francisco Jg2023-01-252023-01-252017-11-16http://hdl.handle.net/10668/11623The nature of dietary fats profoundly affects postprandial hypertriglyceridemia and glucose homeostasis. Niacin is a potent lipid-lowering agent. However, limited data exist on postprandial triglycerides and glycemic control following co-administration of high-fat meals with a single dose of niacin in subjects with metabolic syndrome (MetS). The aim of the study was to explore whether a fat challenge containing predominantly saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs) or MUFAs plus omega-3 long-chain polyunsaturated (LCPUFAs) fatty acids together with a single dose of immediate-release niacin have a relevant role in postprandial insulin and lipid status in subjects with MetS. In a randomized crossover within-subject design, 16 men with MetS were given a single dose of immediate-release niacin (2 g) and ∼15 cal kg-1 body weight meals containing either SFAs, MUFAs, MUFAs plus omega-3 LCPUFAs or no fat. At baseline and hourly over 6 h, plasma glucose, insulin, C-peptide, triglycerides, free fatty acids (FFAs), total cholesterol, and both high- and low-density lipoprotein cholesterol were assessed. Co-administered with niacin, high-fat meals significantly increased the postprandial concentrations of glucose, insulin, C-peptide, triglycerides, FFAs and postprandial indices of β-cell function. However, postprandial indices of insulin sensitivity were significantly decreased. These effects were significantly attenuated with MUFAs or MUFAs plus omega-3 LCPUFAs when compared with SFAs. In the setting of niacin co-administration and compared to dietary SFAs, MUFAs limit the postprandial insulin, triglyceride and FFA excursions, and improve postprandial glucose homeostasis in MetS. © 2017 Society of Chemical Industry.enMUFAsSFAsdietary fatty acidsmetabolic syndromeniacinpostprandialAdultBlood GlucoseDietary FatsFatty AcidsFatty Acids, NonesterifiedHumansInsulinLipid MetabolismLipidsMaleMetabolic SyndromeMiddle AgedNiacinPostprandial PeriodTriglyceridesresearch article28960312open access10.1002/jsfa.87041097-0010https://digital.csic.es/bitstream/10261/166867/1/Postprint_2018_JSFA_V98_P2194.pdf