Lopez-Rodriguez, J CGonzalez, MBogas, GMayorga, CVillalba, MBatanero, E2023-02-092023-02-092020-09-30López-Rodríguez JC, González M, Bogas G, Mayorga C, Villalba M, Batanero E. Epithelial Permeability to Ole e 1 Is More Dependent on the Functional State of the Bronchial Epithelium Than on the Activity of Der p 1 Protease Acting as an Adjuvant to the Bystander Allergen. J Investig Allergol Clin Immunol. 2021 Jul 26;31(4):343-3461018-9068http://hdl.handle.net/10668/16381A dysfunctional epithelial barrier has been widely associated with allergy [1], although it is not clearly established whether this dysfunction is the cause or a consequence of the disease. Moreover, airway epithelial barrier integrity can be impaired by environmental proteases—mostly allergens—derived from a wide variety of biological sources such as mites, cockroaches, food plants, fungi, and pollens [2,3]. These allergens include cysteine proteases, which are potent adjuvants for promoting type 2 helper T-cell immune responses in the airways. Although it is well known that the cysteine protease Der p 1, a major allergen from house dust mite, exerts various effects on the airway epithelium that could contribute to allergic airway diseases [4-6], the cleavage of tight junction (TJ) proteins was the first activity described for it [5].enAllergenBasophilsBronchial epithelium permeabilityDer p 1Ole e 1Adjuvants, ImmunologicAnimalsAntigens, DermatophagoidesAntigens, PlantArthropod ProteinsBasophilsBronchiBystander EffectCysteine EndopeptidasesDermatophagoides pteronyssinusHumansOleaPeptide HydrolasesPermeabilityPlant ProteinsRespiratory MucosaTight Junctionsresearch article33030433Restricted AccessAlérgenosProteasas de CisteínaUniones EstrechasHongosPlantas ComestiblesLinfocitos T Colaboradores-Inductores10.18176/jiaci.0603http://www.jiaci.org/revistas/doi10.18176_jiaci.0603_suppl-material.pdf