Aragón-Vela, JerónimoSolis-Urra, PatricioRuiz-Ojeda, Francisco JavierÁlvarez-Mercado, Ana IsabelOlivares-Arancibia, JorgePlaza-Diaz, Julio2022-05-202022-05-202021-11-10Aragón-Vela J, Solis-Urra P, Ruiz-Ojeda FJ, Álvarez-Mercado AI, Olivares-Arancibia J, Plaza-Diaz J. Impact of Exercise on Gut Microbiota in Obesity. Nutrients. 2021 Nov 10;13(11):3999http://hdl.handle.net/10668/3659Physical activity, exercise, or physical fitness are being studied as helpful nonpharmacological therapies to reduce signaling pathways related to inflammation. Studies describing changes in intestinal microbiota have stated that physical activity could increase the microbial variance and enhance the ratio of Firmicutes/Bacteroidetes, and both actions could neutralize the obesity progression and diminish body weight. The aim of this review is to provide an overview of the literature describing the relationship between physical activity profiles and gut microbiota and in obesity and some associated comorbidities. Promoting physical activity could support as a treatment to maintain the gut microbiota composition or to restore the balance toward an improvement of dysbiosis in obesity; however, these mechanisms need to be studied in more detail. The opportunity to control the microbiota by physical activity to improve health results and decrease obesity and related comorbidities is very attractive. Nevertheless, several incompletely answered questions need to be addressed before this strategy can be implemented.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Gut microbiotaPhysical activityHealthObesityChildrenHumansNon-communicable diseasesMicrobioma gastrointestinalEjercicio físicoSaludObesidadNiñoHumanosEnfermedades no transmisiblesMedical Subject Headings::Organisms::Bacteria::BacteroidetesMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body WeightMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::DysbiosisMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::InflammationMedical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Movement::Motor Activity::ExerciseMedical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesityreview article34836254open access10.3390/nu131139992072-6643PMC8624603