Louro, HenriquetaGomes, Bruno CostaSaber, Anne ThoustrupIamiceli, Anna LauraGöen, ThomasJones, KateKatsonouri, AndromachiNeophytou, Christiana MVogel, UllaVentura, CéliaOberemm, AxelDuca, Radu CorneliuFernandez, Mariana FOlea, NicolasSantonen, TiinaViegas, SusanaSilva, Maria João2023-05-032023-05-032022-08-13Louro H, Gomes BC, Saber AT, Iamiceli AL, Göen T, Jones K, et al. The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe: A Comprehensive Review. Toxics. 2022 Aug 17;10(8):480.http://hdl.handle.net/10668/21589Polycyclic aromatic hydrocarbons (PAHs) are among the chemicals with proven impact on workers' health. The use of human biomonitoring (HBM) to assess occupational exposure to PAHs has become more common in recent years, but the data generated need an overall view to make them more usable by regulators and policymakers. This comprehensive review, developed under the Human Biomonitoring for Europe (HBM4EU) Initiative, was based on the literature available from 2008-2022, aiming to present and discuss the information on occupational exposure to PAHs, in order to identify the strengths and limitations of exposure and effect biomarkers and the knowledge needs for regulation in the workplace. The most frequently used exposure biomarker is urinary 1-hydroxypyrene (1-OH-PYR), a metabolite of pyrene. As effect biomarkers, those based on the measurement of oxidative stress (urinary 8-oxo-dG adducts) and genotoxicity (blood DNA strand-breaks) are the most common. Overall, a need to advance new harmonized approaches both in data and sample collection and in the use of appropriate biomarkers in occupational studies to obtain reliable and comparable data on PAH exposure in different industrial sectors, was noted. Moreover, the use of effect biomarkers can assist to identify work environments or activities of high risk, thus enabling preventive risk mitigation and management measures.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/effect biomarkerexposure biomarkerhuman biomonitoringoccupational exposurepolycyclic aromatic hydrocarbonsHumans1-hydroxypyrenePolycyclic Aromatic Hydrocarbons8-Hydroxy-2'-DeoxyguanosineBiological MonitoringPyrenespyreneOccupational ExposureWorkplaceWorking ConditionsBiomarkersOxidative StressDNAresearch article36006159open access8-Hidroxi-2'-DesoxicoguanosinaADNBiomarcadoresCondiciones de trabajoEstrés oxidativoExposición profesionalHidrocarburos policíclicosAromáticosHumanosLugar de trabajoMonitoreo biológicoPirenos10.3390/toxics100804802305-6304PMC9414426https://www.mdpi.com/2305-6304/10/8/480/pdf?version=1660732365https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414426/pdf