Navarrete-Muñoz, Eva-MariaVioque, JesusToledo, EstefaniaOncina-Canovas, AlejandoMartinez-Gonzalez, Miguel AngelSalas-Salvado, JordiCorella, DoloresFito, MontserratRomaguera, DoraAlonso-Gomez, Angel MWärnberg, JuliaMartínez, J AlfredoSerra-Majem, LuísEstruch, RamonTinahones, Francisco JLapetra, JosePinto, XavierTur, Josep ALopez-Miranda, JoseBueno-Cavanillas, AuroraMatia-Martin, PilarDaimiel, LidiaMartin-Sanchez, VicenteVidal, Josepde-Cos-Blanco, Ana IsabelRos, EmiliDiez-Espino, JavierBabio, NancyFernandez-Carrion, RebecaCastañer, OlgaColom, AntoniCompañ-Gabucio, LauraSalaverria-Lete, ItziarCrespo-Oliva, EdelysAbete, ItziarTomaino, LauraCasas, RosaFernandez-Garcia, Jose CarlosSantos-Lozano, Jose ManuelSarasa, IziarGamez, Jose MGarcia-Rios, Jose M AntonioMartín-Pelaez, SandraRuiz-Canela, MiguelDiaz-Lopez, AndresMartinez-Lacruz, RaulZomeño, Maria DolorsRayo, ElenaGisbert-Selles, CristinaCanudas, SilviaGoday, AlbertGarcía-de-la-Hera, Manoli2023-02-092023-02-092021-03Navarrete-Muñoz EM, Vioque J, Toledo E, Oncina-Canovas A, Martínez-González MÁ, Salas-Salvadó J, et al. Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional study. Eur J Nutr. 2021 Mar;60(2):1125-1136.http://hdl.handle.net/10668/16735We examined the association between dietary folate intake and a score of MetS (metabolic syndrome) and its components among older adults at higher cardiometabolic risk participating in the PREDIMED-Plus trial. A cross-sectional analysis with 6633 with overweight/obesity participants with MetS was conducted. Folate intake (per 100 mcg/day and in quintiles) was estimated using a validated food frequency questionnaire. We calculated a MetS score using the standardized values as shown in the formula: [(body mass index + waist-to-height ratio)/2] + [(systolic blood pressure + diastolic blood pressure)/2] + plasma fasting glucose-HDL cholesterol + plasma triglycerides. The MetS score as continuous variable and its seven components were the outcome variables. Multiple robust linear regression using MM-type estimator was performed to evaluate the association adjusting for potential confounders. We observed that an increase in energy-adjusted folate intake was associated with a reduction of MetS score (β for 100 mcg/day = - 0.12; 95% CI: - 0.19 to - 0.05), and plasma fasting glucose (β = - 0.03; 95% CI: - 0.05 to - 0.02) independently of the adherence to Mediterranean diet and other potential confounders. We also found a positive association with HDL-cholesterol (β = 0.07; 95% CI: 0.04-0.10). These associations were also observed when quintiles of energy-adjusted folate intake were used instead. This study suggests that a higher folate intake may be associated with a lower MetS score in older adults, a lower plasma fasting glucose, and a greater HDL cholesterol in high-risk cardio-metabolic subjects.enFolate intakeDietary intakeCardiometabolic riskObesityOverweightBlood pressureGlucose metabolismTriglyceridesDietary SupplementsDiet, MediterraneanMetabolic SyndromeCross-Sectional StudiesLinear ModelsAgedRisk Factorsresearch article32833162Restricted AccessFolatoSuplementos dietéticosDieta mediterráneaSíndrome metabólicoObesidadSobrepesoPresión arterialGlucosa en sangreColesterol HDLTriglicéridosFactores de riesgo10.1007/s00394-020-02364-41436-6215https://link.springer.com/content/pdf/10.1007/s00394-020-02364-4.pdf