Rivera-Izquierdo, MarioValero-Ubierna, María del CarmenR-delAmo, Juan LuisFernández-García, Miguel ÁngelMartínez-Diz, SilviaTahery-Mahmoud, ArezuRodríguez-Camacho, MartaGámiz-Molina, Ana BelénBarba-Gyengo, NicolásGámez-Baeza, PabloCabrero-Rodríguez, CeliaGuirado-Ruiz, Pedro AntonioMartín-Romero, Divina TatianaLáinez-Ramos-Bossini, Antonio JesúsSánchez-Pérez, María RosaMancera-Romero, JoséGarcía-Martín, MiguelMartín-delosReyes, Luis MiguelMartínez-Ruiz, VirginiaLardelli-Claret, PabloJiménez-Mejías, Eladio2021-04-132021-04-132020-06-25Rivera-Izquierdo M, del Carmen Valero-Ubierna M, R-delAmo JL, Fernández-García MÁ, Martínez-Diz S, Tahery-Mahmoud A, et al. Sociodemographic, clinical and laboratory factors on admission associated with COVID-19 mortality in hospitalized patients: A retrospective observational study. PLoS One. 2020 Jun 25;15(6):e0235107.http://hdl.handle.net/10668/3286Background: To identify and quantify associations between baseline characteristics on hospital admission and mortality in patients with COVID-19 at a tertiary hospital in Spain. Methods and findings: This retrospective case series included 238 patients hospitalized for COVID-19 at Hospital Universitario Clínico San Cecilio (Granada, Spain) who were discharged or who died. Electronic medical records were reviewed to obtain information on sex, age, personal antecedents, clinical features, findings on physical examination, and laboratory results for each patient. Associations between mortality and baseline characteristics were estimated as hazard ratios (HR) calculated with Cox regression models. Series mortality was 25.6%. Among patients with dependence for basic activities of daily living, 78.7% died, and among patients residing in retirement homes, 80.8% died. The variables most clearly associated with a greater hazard of death were age (3% HR increase per 1-year increase in age; 95%CI 1-6), diabetes mellitus (HR 2.42, 95%CI 1.43-4.09), SatO2/FiO2 ratio (43% HR reduction per 1-point increase; 95%CI 23-57), SOFA score (19% HR increase per 1-point increase, 95%CI 5-34) and CURB-65 score (76% HR increase per 1-point increase, 95%CI 23-143). Conclusions: The patients residing in retirement homes showed great vulnerability. The main baseline factors that were independently associated with mortality in patients hospitalized for COVID-19 were older age, diabetes mellitus, low SatO2/FiO2 ratio, and high SOFA and CURB-65 scores.enRetrospective StudiesCOVID-19Coronavirus infectionsRisk factorsHospitalizationResidence characteristicsDemographySociodemographicSpainEstudios retrospectivosInfecciones por coronavirusFactores de riesgoHospitalizaciónCaracterísticas de la residenciaDemografíaEspañaAndalucíaMedical Subject Headings::Anthropology, Education, Sociology and Social Phenomena::Human Activities::Activities of Daily LivingMedical Subject Headings::Persons::Persons::Age Groups::AdultMedical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Age FactorsMedical Subject Headings::Persons::Persons::Age Groups::Adult::AgedMedical Subject Headings::Persons::Persons::Age Groups::Adult::Aged::Aged, 80 and overMedical Subject Headings::Diseases::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus InfectionsMedical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::ComorbidityMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Persons::Persons::Age Groups::Adult::Middle AgedMedical Subject Headings::Health Care::Environment and Public Health::Public Health::Disease Outbreaks::Epidemics::PandemicsMedical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies::Retrospective StudiesMedical Subject Headings::Health Care::Environment and Public Health::Public Health::Epidemiologic Factors::Causality::Risk FactorsMedical Subject Headings::Health Care::Population Characteristics::DemographyMedical Subject Headings::Health Care::Population Characteristics::Demography::Residence CharacteristicsMedical Subject Headings::Health Care::Health Care Facilities, Manpower, and Services::Health Services::Patient Care::HospitalizationMedical Subject Headings::Geographical Locations::Geographic Locations::Europe::Spainresearch article32584868open access10.1371/journal.pone.02351071932-6203PMC7316360