Battaglia, MCSchardt, DEspino, JMGallardo, MICortés-Giraldo, MAQuesada, JMLallena, AMMiras, HGuirado, D2017-06-022017-06-022016-06Battaglia MC, Schardt D, Espino JM, Gallardo MI, Cortés-Giraldo MA, Quesada JM,et al. Dosimetric response of radiochromic films to protons of low energies in the Bragg peak region. Physical Review Accelerators and Beams. 2016, vol.19(6), pp. 064701http://hdl.handle.net/10668/2694One of the major advantages of proton or ion beams, applied in cancer treatment, is their excellent depthdose profile exhibiting a low dose in the entrance channel and a distinct dose maximum (Bragg peak) near the end of range in tissue. In the region of the Bragg peak, where the protons or ions are almost stopped, experimental studies with low-energy particle beams and thin biological samples may contribute valuable information on the biological effectiveness in the stopping region. Such experiments, however, require beam optimization and special dosimetry techniques for determining the absolute dose and dose homogeneity for very thin biological samples. At the National Centre of Accelerators in Seville, one of the beam lines at the 3MV Tandem Accelerator was equipped with a scattering device, a special parallelplate ionization chamber with very thin electrode foils and target holders for cell cultures. In this work, we present the calibration in absolute dose of EBT3 films [Gafchromic radiotherapy films, http://www.ashland.com/products/gafchromic‑radiotherapy‑films] for proton energies in the region of the Bragg peak, where the linear energy transfer increases and becomes more significant for radiobiology studies, as well as the response of the EBT3 films for different proton energy values. To irradiate the films in the Bragg peak region, the energy of the beam was degraded passively, by interposing Mylar foils of variable thickness to place the Bragg peak inside the active layer of the film. The results obtained for the beam degraded in Mylar foils are compared with the dose calculated by means of the measurement of the beam fluence with an ionization chamber and the energy loss predicted by SRIM2008 code.enCalibraciónElectrodosNeoplasmasIonesTereftalatos polietilenosProtonesTransferencia lineal de energíaProtonesRadiobiologíaMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::CalibrationMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Equipment and Supplies::Electrical Equipment and Supplies::ElectrodesMedical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Electrolytes::IonsMedical Subject Headings::Phenomena and Processes::Physical Phenomena::Biophysical Phenomena::Biophysical Processes::Energy Transfer::Linear Energy TransferMedical Subject Headings::Diseases::NeoplasmsMedical Subject Headings::Phenomena and Processes::Physical PhenomenaMedical Subject Headings::Chemicals and Drugs::Macromolecular Substances::Polymers::Polyesters::Polyethylene TerephthalatesMedical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Electrolytes::Ions::Cations::Cations, Monovalent::ProtonsMedical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Radiobiologyresearch articleopen access10.1103/PhysRevAccelBeams.19.0647012469-9888