Rodríguez-Gómez, IsabelWangensteen, RosemaryPérez-Abud, RocíoQuesada, AndrésMoral, Raimundo G DelOsuna, AntonioO'Valle, FranciscoLuna, Juan de DiosVargas, Félix2013-10-112013-10-112012-12Rodríguez-Gómez I, Wangensteen R, Pérez-Abud R, Quesada A, Del Moral RG, Osuna A, et al. Long-term consequences of uninephrectomy in male and female rats. Hypertension. 2012 ; 60(6):1458-630194-911Xhttp://hdl.handle.net/10668/1327Journal Article; Research Support, Non-U.S. Gov't;We investigated the effects of uninephrectomy (UNX) in 6-week-old male and female rats on blood pressure (BP), renal sodium handling, salt sensitivity, oxidative stress, and renal injury over 18 months postsurgery, studying control sham-operated and UNX-operated rats at 6, 12, and 18 months postsurgery, evaluating their renal sodium handling, BP, urinary isoprostanes, N-acetyl-β-D-glucosaminidase, and proteinuria before and after a 2-week high-salt intake period. At 18 months, plasma variables were measured and kidney samples were taken for the analysis of renal morphology and tissue variables. BP was increased at 6 months in male UNX rats versus controls and at 12 and 18 months in both male and female UNX rats and was increased in male versus female UNX groups at 18 months. UNX did not affect water and sodium excretion under basal conditions and after the different test in male and female rats at different ages. However, the renal function curve was shifted to the right in both male and female UNX rats. High-salt intake increased BP in both UNX groups at 6, 12, and 18 months and in the female control group at 18 months, and it increased proteinuria, N-acetyl-β-D-glucosaminidase, and isoprostanes in both UNX groups throughout the study. Renal lesions at 18 months were more severe in male versus female UNX rats. In summary, long-term UNX increased the BP, creatinine, proteinuria, pathological signs of renal injury, and salt sensitivity. Earlier BP elevation was observed and morphological lesions were more severe in male than in female UNX rats.enUninephrectomyrenal sodium handlingrenal injuryblood pressureratPresión ArterialFemeninoRiñónMasculinoNefrectomíaEstrés OxidativoProteinuriaRatasRatas WistarFactores SexualesSodioMedical Subject Headings::Phenomena and Processes::Circulatory and Respiratory Physiological Phenomena::Cardiovascular Physiological Phenomena::Hemodynamics::Blood PressureMedical Subject Headings::Check Tags::FemaleMedical Subject Headings::Anatomy::Urogenital System::Urinary Tract::KidneyMedical Subject Headings::Check Tags::MaleMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Urogenital Surgical Procedures::Urologic Surgical Procedures::NephrectomyMedical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative StressMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Urological Manifestations::ProteinuriaMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::RatsMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats::Rats, WistarMedical Subject Headings::Health Care::Environment and Public Health::Public Health::Epidemiologic Factors::Sex FactorsMedical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Metals::Metals, Alkali::SodiumMedical Subject Headings::Organisms::Eukaryota::Animalsresearch article23071124open access10.1161/HYPERTENSION AHA.112.1984991524-4563