Neukam, KarinEspinosa, NuriaMerino, DoloresRivero-Juárez, AntonioCarrero, AnaRíos, María JoséRuiz-Morales, JosefaGómez-Berrocal, AnaTéllez, FranciscoDíaz-Menéndez, MartaCollado, AntonioPérez-Camacho, InésDelgado-Fernández, MarcialVera-Méndez, FranciscoPineda, Juan A.2016-11-182016-11-182014-11-02Neukam K, Espinosa N, Merino D, Rivero-Juárez A, Carrero A, Ríos Mj, et al. Hepatic safety of RPV/FTC/TDF single tablet regimen in HIV/HCV-coinfected patients. Preliminary results of the hEPAtic Study. J Int AIDS Soc.. 2014, 17(Suppl 3):19631http://hdl.handle.net/10668/2533Although hepatotoxicity related to antiretroviral treatment (ART) has become less frequent, hepatotoxic events, such as transaminase elevations (TE), are still a matter of concern. RPV/FTC/TDF (EPA) is a new single tablet regimen which is widely used in real life practice. Clinical trials showed an adequate profile of liver safety in the sub-population of HIV/HCV- coinfected patients receiving rilpivirine. However, the number of individuals included in these analyses is low [1]. The aim of this ongoing study is to evaluate the incidence of TE and total bilirubin elevations (TBE) during the first 48 weeks of EPA-based therapy in a large population of HIV/HCV-coinfected subjects outside of clinical trials.enBilirrubinaProtocolos clínicosCoinfecciónHepatitis CCombinación emtricitabina, rilpivirina y tenofovirMedical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Azoles::Pyrroles::Tetrapyrroles::Bile Pigments::BilirubinMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Clinical ProtocolsMedical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::CoinfectionMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective AgentsMedical Subject Headings::Diseases::Virus Diseases::Hepatitis, Viral, Human::Hepatitis CMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up StudiesMedical Subject Headings::Diseases::Virus Diseases::RNA Virus Infections::Retroviridae Infections::Lentivirus Infections::HIV InfectionsMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::IncidenceMedical Subject Headings::Anatomy::Digestive System::LiverMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Nitriles::RilpivirineEmtricitabine, Rilpivirine, Tenofovir Drug CombinationMedical Subject Headings::Geographicals::Geographic Locations::Europe::SpainMedical Subject Headings::Chemicals and Drugs::Pharmaceutical Preparations::Dosage Forms::TabletsMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Nitrogenous Group Transferases::Transaminasesconference presentation25394135open access10.7448/IAS.17.4.196311758-2652PMC4224834