Hernanz de Lucas, RaúlNuñez Fernández, MíriamGómez-Caamaño, AntonioMorera López, RosaFortes de la Torre, Inmaculadade la Torre Tomás, AlejandroMuñoz-Garzón, VíctorLópez Bermudo, CristinaMañas Rueda, Ana2023-02-092023-02-092020-12-08http://hdl.handle.net/10668/16753Aim: The CAVIDIOR study evaluated quality of life (QoL) in patients with breakthrough cancer pain receiving palliative radiation therapy in radiation oncology departments (RODs) in Spain. Patients & methods: Prospective observational study at 11 Spanish RODs (July 2016-November 2017). QoL was assessed using Short Form Health Survey 12. Secondary end points were sleep quality, caregiver burden and patient/perception of improvement. Results: QoL improved according to the Short Form Health Survey 12 mental component. Sleep quality and caregivers' burden improved significantly. Conclusion: Breakthrough cancer pain is highly prevalent and can be substantially reduced with appropriate diagnosis and management in RODs. Along with the QoL questionnaire, sleep quality and caregiver burden provide a more comprehensive assessment of overall health status in patients receiving radiation therapy in RODs. Clinical trial registration: NCT02836379 (ClinicalTrials.gov).enAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/breakthrough cancer painpalliative carequality of liferadiation oncologytransmucosal fentanylAdultAgedAged, 80 and overBreakthrough PainCancer PainCaregiversFemaleHumansMaleMiddle AgedNeoplasmsPain MeasurementPalliative CareProspective StudiesQuality of LifeRadiation OncologySpainresearch article33289432open access10.2217/fon-2020-10631744-8301https://doi.org/10.2217/fon-2020-1063