González-Moles, Miguel ÁngelRamos-García, PabloWarnakulasuriya, Saman2022-03-312022-03-312021-07-21González-Moles MÁ, Ramos-García P, Warnakulasuriya S. A Scoping Review on Gaps in the Diagnostic Criteria for Proliferative Verrucous Leukoplakia: A Conceptual Proposal and Diagnostic Evidence-Based Criteria. Cancers. 2021;13(15):3669http://hdl.handle.net/10668/3507Proliferative verrucous leukoplakia (PVL) is considered as an oral potentially malignant disorder (OPMD) that presents with a high tendency to recurrence after treatment and has the highest malignant transformation ratio among all OPMD (50%). Evidence-based publications have indicated that the malignant evolution reported is significantly related to the inconsistent diagnostic criteria used in primary-level studies; so, it has been hypothesized that the risk of oral cancer for this disease could even be underestimated. This is important because PVL requires specific management protocols, evidence-based, aimed at the early diagnosis of cancer developing in these lesions. We present a scoping review-a novel approach to mapping the available literature on a given topic to provide an overview of the available research evidence and to highlight possible gaps in the evidence-especially related in our study to the diagnostic aspects of PVL, and to issue a conceptual proposal and diagnostic criteria for PVL. We conclude that PVL is a white, multifocal and progressive lesion with a high malignant transformation rate which is diagnosed mainly around the age of 60 years without any specific histological characterization. We also advise a personal reflection on the level of certainty with which the clinician makes the diagnosis of a particular case of PVL.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Proliferative verrucous leukoplakiaOral cancerEarly diagnosisDiagnostic criteriaScoping reviewNeoplasias de la bocaDiagnóstico precozMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Early Diagnosis::Early Detection of CancerMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Head and Neck Neoplasms::Mouth NeoplasmsMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Head and Neck Neoplasms::Mouth Neoplasms::Leukoplakia, OralMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humansreview article34359571Acceso abierto10.3390/cancers131536692072-6694PMC8345058