Nieto-Quero, AndreaChaves-Peña, PatriciaSantín, Luis J.Pérez-Martín, MargaritaPedraza, Carmen2022-05-182022-05-182021-06-18Nieto-Quero A, Chaves-Peña P, Santín LJ, Pérez-Martín M, Pedraza C. Do changes in microglial status underlie neurogenesis impairments and depressive-like behaviours induced by psychological stress? A systematic review in animal models. Neurobiol Stress. 2021 Jun 18;15:100356http://hdl.handle.net/10668/3640Stress may have a negative effect on mental health and is the primary environmental risk factor in the aetiology of depression. Nevertheless, the neurobiological mechanisms underlying this mood disorder remain poorly characterized. The hippocampus is a target structure of the adverse effects of stress, and hippocampal neurogenesis plays a crucial role. However, we do not know the mechanisms by which stress impacts neurogenesis. Recent studies indicate that changes in neuroinflammation, primarily via microglial cells, may play an essential role in this process. However, the relationship between stress, microglial changes, and alterations in neurogenesis and their involvement in the development of depression is poorly characterized. For this reason, this systematic review aims to synthesise and evaluate current studies that have investigated the relationship between these variables. Taken together, the revised data, although not entirely conclusive, seem to suggest that microglial changes induced by psychological stress regulate neurogenesis and in turn may be responsible for the development of depressive-like behaviours, but other factors that influence these stressful experiences should not be dismissed.enAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Psychosocial stressNeurogenesisMicrogliaNeuroinflammationDepressionAnimal modelsSystematic reviewNeurogénesisModelos animalesMicroglíaNeurogénesisDepresiónModelos animalesRevisión sistemáticaMedical Subject Headings::Anatomy::Nervous System::Neuroglia::MicrogliaMedical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::DepressionMedical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental HealthMedical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Differentiation::NeurogenesisMedical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Limbic System::HippocampusMedical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::Stress, PsychologicalMedical Subject Headings::Psychiatry and Psychology::Mental Disorders::Mood DisordersMedical Subject Headings::Organisms::Eukaryota::Animalsresearch article34355047Acceso abierto10.1016/j.ynstr.2021.1003562352-2895PMC8319800