Association between the APOA2 rs3813627 Single Nucleotide Polymorphism and HDL and APOA1 Levels Through BMI.

Boughanem, HatimBandera-Merchán, BorjaHernández-Alonso, PabloMoreno-Morales, NoeliaTinahones, Francisco JoséLozano, JoséMorcillo, SonsolesMacias-Gonzalez, Manuel2025-01-072025-01-072020-02-272227-9059https://hdl.handle.net/10668/24784Background: The interaction between obesity and genetic traits on high density lipoprotein (HDL) levels has been extensively studied. The variance of serum HDL has a strong genetic heritability, although the studied variant only explains a small part of this variation. The goal of this study was to investigate the associations between the apolipoprotein type 2 (APOA2) rs3813627 single nucleotide polymorphism (SNP) and anthropometric and biochemical variables, though body mass index (BMI). Methods: This study included 153 subjects (91 overweight/obese (BMI³25 kg/m2) and 62 non-obese individuals (BMIenAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/APOA1APOA2BMIHDLSNPrs3813627Association between the APOA2 rs3813627 Single Nucleotide Polymorphism and HDL and APOA1 Levels Through BMI.research article32120838open access10.3390/biomedicines8030044PMC7148512https://www.mdpi.com/2227-9059/8/3/44/pdf?version=1584496446https://pmc.ncbi.nlm.nih.gov/articles/PMC7148512/pdf