Dierssen-Sotos, TrinidadPalazuelos-Calderon, CamiloJimenez-Moleon, Jose-JuanAragones, NuriaAltzibar, Jone MCastaño-Vinyals, GemmaMartin-Sanchez, VicenteGomez-Acebo, InesGuevara, MarcelaTardon, AdoninaPerez-Gomez, BeatrizAmiano, PilarMoreno, VictorMolina, Antonio JAlonso-Molero, JessicaMoreno-Iribas, ConchiKogevinas, ManolisPollan, MarinaLlorca, Javier2023-01-252023-01-252018-03-06Dierssen-Sotos T, Palazuelos-Calderón C, Jiménez-Moleón JJ, Aragonés N, Altzibar JM, Castaño-Vinyals G, et al. Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project. BMC Cancer. 2018 Mar 12;18(1):280.http://hdl.handle.net/10668/12233Reproductive factors are well known risk factors for breast cancer; however, little is known about how genetic variants in hormonal pathways interact with that relationship. One thousand one hundred thirty nine cases of breast cancer in women and 1322 frequency-matched controls were compared. Genetic variants in hormonal pathways (identified in the Kyoto Encyclopedia of Genes and Genomes) were screened according to their relationship with breast cancer using the Cochran-Armitage statistic. Information on reproductive factors was obtained using a face-to-face questionnaire. The interaction among the selected genetic variants and reproductive factors was tested with logistic regression. Concerning C allele in rs2229712, compared to nulliparity in non-carriers the ORs for 1-2 and > 2 deliveries were 0.48 (0.28-0.81) and 0.34 (0.19-0.59), and in C carriers they were 0.92 (0.42-1.98) and 0.71 (0.31-1.61). Similar results were found in women carrying the C allele in rs1269851. Carriers of Allele T in rs35652107 and allele C in rs6018027 had the delivery number effect more pronounced. The number of deliveries had a dose-response protective effect on breast cancer; women carrying C allele in rs2229712 did not benefit from this protective effect.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Breast cancerGenetic interactionsReproductive factorsActivating Transcription Factor 6AdultAgedAllelesBasic-Leucine Zipper Transcription FactorsBreast NeoplasmsCyclic AMP Response Element-Binding ProteinFemaleGenetic Predisposition to DiseaseHormonesHumansMetabolic Networks and PathwaysMiddle AgedMutationNerve Tissue ProteinsParityPolymorphism, Single NucleotidePregnancyReproductionRibosomal Protein S6 Kinases, 90-kDaRisk FactorsSpainSurveys and Questionnairessrc-Family Kinasesresearch article29530003open accessAdultoAlelosAncianoEmbarazoEspañaFactores de transcripción con cremalleras de leucina de carácter básicoFactores de riesgoFamilia-src quinasasFemeninoHormonasHumanosMutaciónNeoplasias de la mama10.1186/s12885-018-4182-31471-2407PMC5848450https://doi.org/10.1186/s12885-018-4182-3https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848450/pdf