Park, Jin YoungBueno-de-Mesquita, H BasFerrari, PietroWeiderpass, Elisabetede Batlle, JordiTjønneland, AnneKyro, CecilieRebours, VincianeBoutron-Ruault, Marie-ChristineMancini, Francesca RomanaKatzke, VerenaKühn, TilmanBoeing, HeinerTrichopoulou, AntoniaLa Vecchia, CarloKritikou, MariaMasala, GiovannaPala, ValeriaTumino, RosarioPanico, SalvatorePeeters, Petra HSkeie, GuriMerino, SusanaDuell, Eric JRodríguez-Barranco, MiguelDorronsoro, MirenChirlaque, Maria-DoloresArdanaz, EvaGylling, BjörnSchneede, JörnEricson, UlrikaSternby, HannaKhaw, Kay-TeeBradbury, Kathryn EHuybrechts, IngeAune, DagfinnVineis, PaoloSlimani, Nadia2023-01-252023-01-252018-12-21http://hdl.handle.net/10668/12900Pancreatic cancer (PC) has an exceptionally low survival rate and primary prevention strategies are limited. Folate plays an important role in one-carbon metabolism and has been associated with the risk of several cancers, but not consistently with PC risk. We aimed to investigate the association between dietary folate intake and PC risk, using the standardised folate database across 10 European countries. A total of 477,206 participants were followed up for 11 years, during which 865 incident primary PC cases were recorded. Folate intake was energy-adjusted using the residual method. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. In multivariable analyses stratified by age, sex, study centre and adjusted for energy intake, smoking status, BMI, educational level, diabetes status, supplement use and dietary fibre intake, we found no significant association between folate intake and PC risk: the HR of PC risk for those in the highest quartile of folate intake (≥353 μg/day) compared to the lowest (enEPIC studydietary folate intakepancreatic cancerAdultEuropeFemaleFolic AcidFollow-Up StudiesHumansMaleMiddle AgedNutritional StatusPancreatic NeoplasmsProportional Hazards ModelsProspective StudiesSelf ReportSmokingresearch article30178496open access10.1002/ijc.318301097-0215https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.31830