de Rojas, ItziarHernández, IsabelMontrreal, LauraQuintela, InésCalero, MiguelRoyo, Jose LuísHuerto Vilas, RaquelGonzález-Pérez, AntonioFranco-Macías, EmilioMacías, JuanMenéndez-González, ManuelFrank-García, AnaDiez-Fairen, MónicaLage, CarmenGarcía-Madrona, SebastiánAguilera, NuriaGarcía-González, PabloPuerta, RaquelSotolongo-Grau, OscarAlonso-Lana, SilviaRábano, AlbertoArias Pastor, AlfonsoPastor, Ana BelénCorma-Gómez, AnaïsMartín Montes, AngelMartínez Rodríguez, CarmenBuiza-Rueda, DoloresPeriñán, Maria TeresaRodriguez-Rodriguez, EloyAlvarez, IgnacioRosas Allende, IrenePineda, Juan ABernal Sánchez-Arjona, MaríaFernández-Fuertes, MartaMendoza, SilviaDel Ser, TeodoroGr Ace/Degesco Consortium,Garcia-Ribas, GuillermoSánchez-Juan, PascualPastor, PauBullido, María JÁlvarez, VictoriaReal, Luis MMir, PabloPiñol-Ripoll, GerardGarcía-Alberca, Jose MaríaMedina, MiguelOrellana, AdelinaButler, Chris RMarquié, MartaSáez, María EugeniaCarracedo, ÁngelTárraga, LluísBoada, MercèRuiz, Agustín2025-01-072025-01-072021-12-072075-4426https://hdl.handle.net/10668/27278Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study using the GR@ACE/DEGESCO study, searching for susceptibility factors associated with COVID-19 disease. To this end, we compared 221 COVID-19 confirmed cases with 17,035 individuals in whom the COVID-19 disease status was unknown. Then, we performed a meta-analysis with the publicly available data from the COVID-19 Host Genetics Initiative. Because the APOE locus has been suggested as a potential modifier of COVID-19 disease, we added sensitivity analyses stratifying by dementia status or by disease severity. We confirmed the existence of the 3p21.31 region (LZTFL1, SLC6A20) implicated in the susceptibility to SARS-CoV-2 infection and TYK2 gene might be involved in COVID-19 severity. Nevertheless, no statistically significant association was observed in the COVID-19 fatal outcome or in the stratified analyses (dementia-only and non-dementia strata) for the APOE locus not supporting its involvement in SARS-CoV-2 pathobiology or COVID-19 prognosis.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/APOECOVID-19GR@ACE/DEGESCOGWASSARS-CoV-2dementiaresearch article34945790open access10.3390/jpm11121318PMC8708271https://www.mdpi.com/2075-4426/11/12/1318/pdf?version=1638872094https://pmc.ncbi.nlm.nih.gov/articles/PMC8708271/pdf