Rivero-Juarez, AntonioVallejo, NicolauLopez-Lopez, PedroDíaz-Mareque, Ana IsabelFrias, MarioVallejo, AldaraCaballero-Gómez, JavierRodríguez-Velasco, MaríaMolina, EstherAguilera, Antonio2022-07-292022-07-292019-12-26Rivero-Juarez A, Vallejo N, Lopez-Lopez P, Díaz-Mareque AI, Frias M, Vallejo A, et al. Ribavirin as a First Treatment Approach for Hepatitis E Virus Infection in Transplant Recipient Patients. Microorganisms. 2019 Dec 26;8(1):51http://hdl.handle.net/10668/3849The hepatitis E virus (HEV) is the major cause of acute hepatitis of viral origin worldwide. Despite its usual course as an asymptomatic self-limited hepatitis, there are highly susceptible populations, such as those with underlying immunosuppression, which could develop chronic hepatitis. In this situation, implementation of therapy is mandatory in the sense to facilitate viral clearance. Currently, there are no specific drugs approved for HEV infection, but ribavirin (RBV), the drug of choice, is used for off-label treatment. Here, we present two cases of chronic HEV infection in transplant patients, reviewing and discussing the therapeutic approach available in the literature. The use of RBV for the treatment of an HEV infection in organ transplant patients seems to be effective. The recommendation of 12 weeks of therapy is adequate in terms of efficacy. Nevertheless, there are important issues that urgently need to be assessed, such as optimal duration of therapy and drug dosage.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/HEVTreatmentZoonosesRibavirinTransplantVirus de la hepatitis ETerapéuticaZoonosisRibavirinaTrasplantesMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Organisms::Viruses::Hepatitis Viruses::Hepatitis E virusMedical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleosides::Ribonucleosides::RibavirinMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Prescriptions::Off-Label UseMedical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases::Hepatitis::Hepatitis, ChronicMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Transplantation::Organ TransplantationMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy::ImmunosuppressionMedical Subject Headings::Diseases::Virus Diseases::Hepatitis, Viral, Human::Hepatitis Eresearch article31888090open access10.3390/microorganisms80100512076-2607PMC7022260