Aviles Bueno, BeatrizSoler, Maria JosePerez-Belmonte, LuisJimenez Millan, AnabelRivas Ruiz, FranciscoGarcia de Lucas, Maria Dolores2023-05-032023-05-032022-04-112048-8505http://hdl.handle.net/10668/19746Semaglutide [glucagon-like peptide-1 receptor-agonist (GLP-1RA)] has shown nephroprotective effects in previous cardiovascular studies. However, its efficacy and safety in patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) have been rarely studied. This is a multicenter, retrospective, observational study in patients with T2D and CKD with glycosylated hemoglobin A1c (HbA1c) of 7.5-9.5% treated with subcutaneous semaglutide for 12 months in real-world clinical practice. The main objectives were glycemic control as HbA1c 5%. We studied a total of 122 patients, ages 65.50 ± 11 years, 62% men, duration of T2D 12 years, baseline HbA1c 7.57% ± 1.36% and an estimated glomerular filtration rate (eGFR) 50.32 ± 19.21 mL/min/1.73 m2; 54% had a urinary albumin:creatinine ratio (UACR) of 30-300 mg/g and 20% had a UACR >300 mg/g. After 12 months of follow-up, HbA1c declined -0.73% ± 1.09% (P 300 mg/g. After 12 months of follow-up, HbA1c declined -0.73% ± 1.09% (P 5% of their body weight. Systolic and diastolic blood pressure decreased -9.85 mmHg and -5.92 mmHg, respectively (P 300 mg/g). The mean eGFR (by the Chronic Kidney Disease Epidemiology Collaboration) remained stable. The need for basal insulin decreased 20% (P In this real-world study, patients with T2D and CKD treated with subcutaneous semaglutide for 12 months significantly improved glycemic control and decreased weight. Albuminuria decreased by >50% in patients with macroalbuminuria. The administration of GLP-1RA in patients with T2D and CKD was safe and well tolerated.enAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/GLP-1RAalbuminuriadiabetic chronic diseaseobesitysemaglutideresearch article35892023open access10.1093/ckj/sfac096PMC9308087https://academic.oup.com/ckj/article-pdf/15/8/1593/45051490/sfac096.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308087/pdf